Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking
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DOI: 10.1016/j.biopsych.2016.08.033
Abstract: BACKGROUND Relapse is a two-component process consisting of a highly motivated drug-seeking phase that, if successful, is followed by a drug-using phase resulting in temporary satiation. In rodents, cue-induced drug seeking requires transient synaptic potentiation… read more here.
Keywords: cocaine use; drug seeking; drug; cocaine ... See more keywords
Astrocytes as cellular mediators of cue reactivity in addiction.
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DOI: 10.1016/j.coph.2020.07.009
Abstract: Relapse to addictive drug use remains a major medical problem worldwide. In rodents, glutamate release in the nucleus accumbens core triggers reinstated drug seeking in response to stress, and drug-associated cues and contexts. Glutamatergic dysregulation… read more here.
Keywords: addiction; cellular mediators; drug seeking; drug ... See more keywords
Cocaine Seeking During Initial Abstinence Is Driven by Noradrenergic and Serotonergic Signaling in Hippocampus in a Sex-Dependent Manner
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.150
Abstract: There is evidence for sex differences in cocaine addiction from both clinical and preclinical studies. In particular, preclinical studies indicate that females may be more sensitive than males to stress-induced drug seeking. The dorsal hippocampus… read more here.
Keywords: seeking initial; initial abstinence; drug seeking; drug ... See more keywords
Ventral pallidum: a promising target for addiction intervention
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DOI: 10.1038/s41386-019-0528-z
Abstract: The ventral pallidum (VP) is part of a “final common pathway” of relapse behavior [1]. The extinction-reinstatement paradigm provides a reliable method to study the neurobiology of drug relapse [2]. Recently, variations on the extinction… read more here.
Keywords: drug seeking; drug; relapse; immunoreactivity ... See more keywords
Addressing the Opioid Crisis: Drug-Seeking Patient Simulation.
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DOI: 10.1097/nne.0000000000000689
Abstract: Many Americans have or have had a bottle of opioids in their medicine cabinets. In previous decades, these powerful painkillers were primarily reserved for cancer-related pain, severe pain (e.g., after surgery), and end-of-life care. In… read more here.
Keywords: drug seeking; seeking patient; addressing opioid; patient simulation ... See more keywords
Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue‐induced reinstatement of drug‐seeking in rats
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DOI: 10.1111/adb.12594
Abstract: Addiction to drugs such as cocaine is marked by cycles of compulsive drug‐taking and drug‐seeking behavior. Although the transition to addiction is thought to recruit neural processes in dorsal striatum, little is known regarding the… read more here.
Keywords: addiction; drug seeking; pathway striatal; drug ... See more keywords
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
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DOI: 10.1371/journal.pone.0271901
Abstract: Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy. Orexins act on two receptor subtypes, OX1R… read more here.
Keywords: sleep wake; orexin; drug seeking; ox2r selective ... See more keywords
Boosting of Thalamic D2 Dopaminergic Transmission: A Potential Strategy for Drug-Seeking Attenuation
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DOI: 10.1523/eneuro.0378-17.2017
Abstract: Abstract This commentary focuses on novel findings by Clark et al. (2017) published in eNeuro, which show that dopamine D2 receptors (D2Rs) in the paraventricular nucleus of the thalamus (PVT) are involved in cocaine sensitization.… read more here.
Keywords: dopaminergic transmission; drug seeking; transmission potential; drug ... See more keywords
Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin/orphanin FQ peptide receptor in rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.983595
Abstract: Buprenorphine, which has been approved for the treatment of opioid dependence, reduces cocaine consumption by co-activating μ-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors. However, the role of buprenorphine in methamphetamine (METH) reinforcement and drug-seeking… read more here.
Keywords: behavior; seeking behavior; buprenorphine; drug seeking ... See more keywords