In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04081-5
Abstract: Purpose Early prediction of clinical response to conventional chemotherapy is a significant factor in determining an overall treatment strategy for osteosarcoma. Methods Cells were extracted from treatment-naïve biopsies from 16 osteosarcoma patients who received a… read more here.
Keywords: clinical outcomes; sensitivity ids; vitro drug; primary osteosarcoma ... See more keywords
Letter to the Editor concerning “Drug sensitivity patterns in Xpert-positive spinal tuberculosis: an observational study of 252 patients” by Upadhyay M, et al. [Eur Spine J (2020) 29:1476–1482]
Sign Up to like & getrecommendations! Published in 2020 at "European Spine Journal"
DOI: 10.1007/s00586-020-06584-4
Abstract: We read with great interest the recent article by Upadhyay et al. on drug sensitivity patterns in Xpert-positive spinal tuberculosis published in this journal [1]. We congratulate the authors for addressing this important topic—drug-resistant tuberculosis… read more here.
Keywords: group; drug; tuberculosis; resistance ... See more keywords
Analysis of drug sensitivity of Escherichia Coli O157H7.
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical microdevices"
DOI: 10.1007/s10544-021-00565-0
Abstract: Sensitive and rapid tests of Escherichia coli drug sensitivity is very important for health of human and animals. An E. coli immunosensor was built based on electrochemical detection and immune detection technologies, through pretreating screen-printed… read more here.
Keywords: escherichia coli; detection; detection system; drug sensitivity ... See more keywords
Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2016.12.016
Abstract: OBJECTIVE Resistance to standard chemotherapy poses a major clinical problem in the treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique ovarian cancer subtype for which efficient treatment options are lacking… read more here.
Keywords: dasatinib mtor; granulosa; drug; sensitivity ... See more keywords
Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Nano Letters"
DOI: 10.1021/acs.nanolett.9b04607
Abstract: Cancer cell–matrix interactions have been shown to enhance cancer cell survival via the activation of pro-survival signaling pathways. These pathways are initiated at the site of interaction, i.e., integrins, and thus, their inhibition has been… read more here.
Keywords: drug sensitivity; drug; cancer cell; cancer ... See more keywords
Network-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52093-w
Abstract: We present the Network-based Biased Tree Ensembles (NetBiTE) method for drug sensitivity prediction and drug sensitivity biomarker identification in cancer using a combination of prior knowledge and gene expression data. Our devised method consists of… read more here.
Keywords: network; tree ensembles; biased tree; drug ... See more keywords
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40361
Abstract: Combination targeted therapy is commonly used to treat acute myeloid leukemia (AML) patients, particularly in refractory/relapse (RR) population. However, concerns have been raised regarding the safety and patient tolerance of combination chemotherapy. It is critical… read more here.
Keywords: acute myeloid; gli1 inhibition; inhibition; drug sensitivity ... See more keywords
Identifying and characterizing drug sensitivity-related lncRNA-TF-gene regulatory triplets
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac366
Abstract: Abstract Recently, many studies have shown that lncRNA can mediate the regulation of TF-gene in drug sensitivity. However, there is still a lack of systematic identification of lncRNA-TF-gene regulatory triplets for drug sensitivity. In this… read more here.
Keywords: gene regulatory; lncrna gene; drug; drug sensitivity ... See more keywords
Link synthetic lethality to drug sensitivity of cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbx172
Abstract: Synthetic lethal (SL) interactions occur when alterations in two genes lead to cell death but alteration in only one of them is not lethal. SL interactions provide a new strategy for molecular-targeted cancer therapy. Currently,… read more here.
Keywords: sensitivity cancer; drug; drug sensitivity; cancer cells ... See more keywords
Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abh3375
Abstract: Tumor tissue collection and processing under physioxia allow highly relevant detection of signaling networks and drug sensitivity. read more here.
Keywords: highly relevant; signaling networks; drug sensitivity; networks drug ... See more keywords
Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda
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DOI: 10.1128/aac.01818-18
Abstract: The potential spread of antimalarial drug resistance to Africa, in particular for artemisinins and key partner drugs, is a major concern. We surveyed Plasmodium falciparum genetic markers associated with drug sensitivity on 3 occasions at… read more here.
Keywords: antimalarial drug; prevalence; drug; sensitivity ... See more keywords