Effects of phosphate on drug solubility behavior of mixture ibuprofen and lidocaine
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2019.110415
Abstract: Abstract Drug solubility is an important characteristic affecting its bioavailability. The properties of ionic drugs affect their sensitivity to buffer composition. We aimed to elucidate the variations in ibuprofen solubility due to different buffers and… read more here.
Keywords: phosphate; drug solubility; solubility behavior; solubility ... See more keywords
Clarithromycin and N-acetylcysteine co-spray-dried powders for pulmonary drug delivery: A focus on drug solubility.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.079
Abstract: Cystic fibrosis (CF) lungs are usually susceptible to Pseudomonas aeruginosa colonization and this bacterium is resistant to immune system clearance and drug control. Particularly, the biofilm mode of growth protects several microorganisms from host defenses… read more here.
Keywords: drug; drug solubility; spray dried; clarithromycin acetylcysteine ... See more keywords
Sink conditions do not guarantee the absence of saturation effects.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.119009
Abstract: Limited drug solubility effects can play a major role for the control of drug release from a variety of drug delivery systems, e.g. tablets, pellets, implants and microparticles. Importantly, such saturation effects can occur inside… read more here.
Keywords: drug solubility; sink conditions; drug; saturation effects ... See more keywords
Neural simulation and experimental investigation of Chloroquine solubility in supercritical solvent
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115942
Abstract: Abstract Understanding drug solubility in various solvents is of great importance to the pharmaceutical industry for design of the process. To date, various modeling approaches including Equation of State (EoS) and Semi-empirical correlations have been… read more here.
Keywords: drug solubility; supercritical solvent; neural simulation; solubility ... See more keywords
Machine Learning Derived Quantitative Structure Property Relationship (QSPR) to Predict Drug Solubility in Binary Solvent Systems
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.8b04584
Abstract: Prediction of drug solubility is a crucial problem in pharmaceutical industries for both drug delivery and discovery purposes. Several theoretical approaches have been proposed to predict drug solubility in mixed solvent systems when the solubility… read more here.
Keywords: drug solubility; quantitative structure; drug; predict drug ... See more keywords
Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2018.1515997
Abstract: Abstract To develop a novel revaprazan-loaded gelatine microsphere with enhanced solubility and oral bioavailability, numerous gelatine microspheres were prepared using a spray-drying technique. The impact of gelatine amount on drug solubility in the gelatine microspheres… read more here.
Keywords: gelatine; oral bioavailability; revaprazan; drug solubility ... See more keywords
Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug's Solubility Improvement
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5883239
Abstract: Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately dosage… read more here.
Keywords: solubility; solubility improvement; drug solubility; drug ... See more keywords
A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood–Brain Barrier Permeability and Targets Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14092207
Abstract: Simple Summary Glioblastoma (GBM) is a fatal and incurable brain cancer, and current treatment options have demonstrated limited success. Here, we describe the use of a dg-Bcan-Targeting-Peptide (BTP-7) that has BBB-penetrating properties and targets GBM.… read more here.
Keywords: brain; btp; gbm; permeability ... See more keywords
Anti-Cancer Drug Solubility Development within a Green Solvent: Design of Novel and Robust Mathematical Models Based on Artificial Intelligence
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165140
Abstract: Nowadays, supercritical CO2(SC-CO2) is known as a promising alternative for challengeable organic solvents in the pharmaceutical industry. The mathematical prediction and validation of drug solubility through SC-CO2 system using novel artificial intelligence (AI) approach has… read more here.
Keywords: solubility; artificial intelligence; drug solubility; drug ... See more keywords