Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid
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DOI: 10.1016/j.ajps.2016.10.001
Abstract: Graphical Abstract Upon dispersion of drug-loaded SMEDDS in aqueous media at various pHs, four drug-related species – Du, Di, Du-SMEDDS and Di-SMEDDS – contribute to total drug solubilization in the formed microemulsions. Distinct solubilization behavior… read more here.
Keywords: effect ionization; drug; solubilization; ionization drug ... See more keywords
Synthesis, self-assembly and drug solubilization of hyperbranched block polyethers
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DOI: 10.1016/j.molliq.2017.11.026
Abstract: Abstract Three hyperbranched block polyethers H3, H5 and H7 with the same PPO block numbers but different PEO contents were synthesized by anionic polymerization. The self-assembly behaviors of H3, H5 and H7 in aqueous solution… read more here.
Keywords: self assembly; block; drug; drug solubilization ... See more keywords
Drug Solubilization by Means of Partition/Association Equilibrium Using a Modified Nanosized Dendrimeric Biopolymer
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DOI: 10.1208/s12249-019-1490-0
Abstract: The objective of this study is to elucidate the combined effects of a novel type of material being investigated as a new excipient, an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB) and poloxamer (PLX), on the solubility of poorly… read more here.
Keywords: biopolymer; drug; solubilization; drug solubilization ... See more keywords