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Published in 2018 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2018.11.003
Abstract: Self-emulsifying and other lipid-based drug delivery systems have drawn considerable interest from pharmaceutical scientists for managing oral delivery of poorly water-soluble compounds. Following administration, self-emulsifying systems exhibit complex aqueous dispersion and digestion in the gastro-intestinal…
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Keywords:
drug supersaturation;
self emulsifying;
lipid based;
digestion ... See more keywords
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Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.06.089
Abstract: HYPOTHESIS Colloidal aggregation phenomena have been found responsible for the supersaturation of poorly water-soluble drugs, potentially leading to bioavailability enhancements. Unlike coarse precipitates, phase separation in the form of colloids, is expected to enhance drug…
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Keywords:
drug supersaturation;
phase;
polymer mediated;
mediated drug ... See more keywords
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Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00122
Abstract: A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution-drug…
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Keywords:
dissolution drug;
drug supersaturation;
drug;
cocrystal dissolution ... See more keywords