Comparative Effectiveness of Regimens for Drug-Susceptible Tuberculous Meningitis in Children and Adolescents: A Systematic Review and Aggregate-Level Data Meta-Analysis
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DOI: 10.1093/ofid/ofac108
Abstract: Abstract Background Before August 2021, the only regimen recommended by the World Health Organization (WHO) to treat pediatric drug-susceptible tuberculous meningitis was a 12-month regimen consisting of isoniazid, rifampicin, ethambutol, and pyrazinamide (2HRZE/10HR). The comparative… read more here.
Keywords: month; susceptible tuberculous; systematic review; comparative effectiveness ... See more keywords
The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome
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DOI: 10.1101/2022.11.20.517260
Abstract: Drug resistance is a known risk factor for poor tuberculosis (TB) treatment outcomes, but the contribution of other bacterial factors to poor outcomes in drug susceptible TB is less understood. Here, we generate a population-based… read more here.
Keywords: tuberculosis; treatment outcomes; poor treatment; drug susceptible ... See more keywords
Impact of prolonged isolation on adolescents with drug-susceptible tuberculosis in Lima, Peru: a qualitative study
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DOI: 10.1136/bmjopen-2022-063287
Abstract: Objectives Patients with tuberculosis (TB) generally are instructed to isolate at the beginning of treatment in order to prevent disease transmission. The duration of isolation varies and may be prolonged (ie, lasting 1 month or more).… read more here.
Keywords: prolonged isolation; adolescents drug; isolation; lima peru ... See more keywords
Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis - United States, 2022.
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DOI: 10.15585/mmwr.mm7108a1
Abstract: On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Trials Group (ACTG) published results from a randomized controlled trial indicating that a 4-month regimen containing rifapentine (RPT),… read more here.
Keywords: tuberculosis; month; regimen treatment; susceptible pulmonary ... See more keywords
Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient
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DOI: 10.3201/eid2511.180638
Abstract: A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is… read more here.
Keywords: drug susceptible; drug; tuberculosis; multidrug resistant ... See more keywords