Corrigendum to “Searching for drug synergy in complex dose–response landscapes using an interaction potency model” [Comput. Struct. Biotechnol. J. 13 (2015) 504–513]
Sign Up to like & getrecommendations! Published in 2017 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2017.07.003
Abstract: [This corrects the article DOI: 10.1016/j.csbj.2015.09.001.]. read more here.
Keywords: dose response; complex dose; synergy complex; corrigendum searching ... See more keywords
Allosteric cross-talk in chromatin can mediate drug-drug synergy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14860
Abstract: Exploitation of drug–drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug–drug synergy mediated by allosteric… read more here.
Keywords: cross talk; allosteric cross; chromatin; drug ... See more keywords
Multi-way relation-enhanced hypergraph representation learning for anti-cancer drug synergy prediction
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac579
Abstract: MOTIVATION Drug combinations have exhibited promise in treating cancers with less toxicity and fewer adverse reactions. However, in vitro screening of synergistic drug combinations is time-consuming and labour-intensive because of the combinatorial explosion. Although a… read more here.
Keywords: multi way; drug combinations; drug synergy; cell lines ... See more keywords
Anticancer drug synergy prediction in understudied tissues using transfer learning
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Medical Informatics Association : JAMIA"
DOI: 10.1093/jamia/ocaa212
Abstract: OBJECTIVE Drug combination screening has advantages in identifying cancer treatment options with higher efficacy without degradation in terms of safety. A key challenge is that the accumulated number of observations in in-vitro drug responses varies… read more here.
Keywords: drug; understudied tissues; synergy prediction; drug synergy ... See more keywords
Few-Shot Drug Synergy Prediction With a Prior-Guided Hypernetwork Architecture.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE transactions on pattern analysis and machine intelligence"
DOI: 10.1109/tpami.2023.3248041
Abstract: Predicting drug synergy is critical to tailoring feasible drug combination treatment regimens for cancer patients. However, most of the existing computational methods only focus on data-rich cell lines, and hardly work on data-poor cell lines.… read more here.
Keywords: cell lines; drug; drug synergy; data poor ... See more keywords
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15418
Abstract: The SARS‐COV‐2 pandemic and the global spread of coronavirus disease 2019 (COVID‐19) urgently call for efficient and safe antiviral treatment strategies. A straightforward approach to speed up drug development at lower costs is drug repurposing.… read more here.
Keywords: treatment; drug; drug synergy; synergy combinatory ... See more keywords
Network Propagation Predicts Drug Synergy in Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0740
Abstract: Combination therapies are commonly used to treat patients with complex diseases that respond poorly to single-agent therapies. In vitro high-throughput drug screening is a standard method for preclinical prioritization of synergistic drug combinations, but it… read more here.
Keywords: synergy; network propagation; drug; drug synergy ... See more keywords
Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040482
Abstract: Fungal infections impact the lives of at least 12 million people every year, killing over 1.5 million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven resistance in many serious fungal pathogens, and there… read more here.
Keywords: synergy expand; augmenting azoles; expand antifungal; synergy ... See more keywords