Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.031
Abstract: Current study is based on the biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives 1-26, by treating metronidazole with different aryl and hetero-aryl carboxylic acids in the presence of 1,1'-carbonyl diimidazole (CDI) as a… read more here.
Keywords: biology oriented; drug synthesis; synthesis biods; biology ... See more keywords
Recent Advances in Biocatalysis for Drug Synthesis
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DOI: 10.3390/biomedicines10050964
Abstract: Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also plays a role in drug discovery and can support many active ingredient… read more here.
Keywords: synthesis; recent advances; drug synthesis; advances biocatalysis ... See more keywords
Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment
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DOI: 10.3390/ijms23073605
Abstract: Environmentally friendly and sustainable processes for the production of active pharmaceutical ingredients (APIs) gain increasing attention. Biocatalytic synthesis routes with enzyme cascades support many stated green production principles, for example, the reduced need for solvents… read more here.
Keywords: industrially relevant; synthesis; enzyme cascades; cascades drug ... See more keywords