Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4709-3
Abstract: RationaleSynthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine… read more here.
Keywords: self administration; drug; mdpv; drug taking ... See more keywords
A synthetic small molecule Isoxazole-9 protects against methamphetamine relapse
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2017.46
Abstract: Adult neurogenesis in the dentate gyrus (DG) is strongly influenced by drug-taking behavior and may have a role in the etiology of drug-seeking behavior. However, mechanistic studies on the relationship of neurogenesis on drug seeking… read more here.
Keywords: neurogenesis; small molecule; drug; drug taking ... See more keywords
Compulsive drug-taking is associated with habenula-frontal cortex connectivity.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208867119
Abstract: Significance The habenula is a relay node between the forebrain and midbrain regions and plays an essential role in making decisions based on the value of choices. Compulsive drug use, as the defining feature of… read more here.
Keywords: habenula frontal; compulsive drug; drug taking; drug ... See more keywords
The Neuroscience of Drug Reward and Addiction.
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DOI: 10.1152/physrev.00014.2018
Abstract: Drug consumption is driven by a drug's pharmacological effects, which are experienced as rewarding, and is influenced by genetic, developmental, and psychosocial factors that mediate drug accessibility, norms, and social support systems or lack thereof.… read more here.
Keywords: addiction; neuroscience drug; drug; drug reward ... See more keywords