Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700762
Abstract: Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono‐ or disaccharides. Galactose, mannose, fucose,… read more here.
Keywords: application mono; disaccharides drug; efficacy; drug ... See more keywords
Magnetic drug targeting simulations in blood flows with fluid-structure interaction.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.2954
Abstract: We present fluid-structure interaction simulations of magnetic drug targeting (MDT) in blood flows. In this procedure, a drug is attached to ferromagnetic particles to externally direct it to a specific target after it is injected… read more here.
Keywords: magnetic drug; structure interaction; drug; fluid structure ... See more keywords
Improved magnetic drug targeting with maximized magnetic forces and limited particle spreading.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.16180
Abstract: BACKGROUND In magnetic drug targeting (MDT), micro- or nanoparticles are injected into the human body to locally deliver therapeutics. These magnetic particles can be guided from a distance by external magnetic fields and gradients from… read more here.
Keywords: magnetic forces; magnetic drug; particle spreading; drug targeting ... See more keywords
Repurposing a drug targeting peptide for targeting antimicrobial peptides against Staphylococcus
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Letters"
DOI: 10.1007/s10529-019-02779-y
Abstract: ObjectivesTargeted therapies seek to selectively eliminate a pathogen without disrupting the resident microbial community. However, with selectivity comes the potential for developing bacterial resistance. Thus, a diverse range of targeting peptides must be made available.ResultsTwo… read more here.
Keywords: targeting peptide; repurposing drug; antimicrobial peptides; targeting antimicrobial ... See more keywords
Nanoarchitectonics: a New Horizon for Drug Targeting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-021-09550-9
Abstract: Nanoarchitectonics is an emerging multidisciplinary field that has the potential to offer trailblazing solutions to various challenging therapies by facilitating precise and tailored control of physicochemical properties, morphology, and also the biological effects of nano-sized… read more here.
Keywords: nanoarchitectonics new; new horizon; drug; horizon drug ... See more keywords
Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Nano Research"
DOI: 10.1007/s12274-018-2126-5
Abstract: The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification,… read more here.
Keywords: drug; treatment rheumatoid; rheumatoid arthritis; drug targeting ... See more keywords
Synthetic chemical ligands and cognate antibodies for biorthogonal drug targeting and cell engineering.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.01.010
Abstract: A vast range of biomedical applications relies on the specificity of interactions between an antigen and its cognate receptor or antibody. This specificity can be highest when said antigen is a non-natural (synthetic) molecule introduced… read more here.
Keywords: synthetic chemical; engineering; drug; chemical ligands ... See more keywords
Bisphosphonate conjugation for bone specific drug targeting
Sign Up to like & getrecommendations! Published in 2018 at "Bone Reports"
DOI: 10.1016/j.bonr.2018.06.007
Abstract: Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved… read more here.
Keywords: drug; bone; drug targeting; bisphosphonate conjugation ... See more keywords
Drug targeting of heme proteins in Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.11.004
Abstract: TB, caused by the human pathogen Mycobacterium tuberculosis (Mtb), causes more deaths than any other infectious disease. Iron is crucial for Mtb to infect the host and to sustain infection, with Mtb encoding large numbers… read more here.
Keywords: drug; heme proteins; proteins mycobacterium; targeting heme ... See more keywords
Drug targeting strategies into the brain for treating neurological diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2018.10.015
Abstract: Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separates the brain from blood and acts as a barrier to protect the brain from microorganisms, neurotoxins… read more here.
Keywords: treating neurological; targeting strategies; brain treating; drug targeting ... See more keywords
Homotopy-based solution of Navier-Stokes equations for two-phase flow during magnetic drug targeting
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.04.106
Abstract: Abstract As one of the promising innovative methods of drug delivery, magnetic drug targeting (MDT) ideally contains three main steps to treat localized diseases; chemically attaching drugs to magnetic nanoparticles and their injection to a… read more here.
Keywords: magnetic drug; two phase; drug; homotopy ... See more keywords