Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28306
Abstract: Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently spreading throughout the world and prevention… read more here.
Keywords: potential drug; monkeypox virus; targets management; drug ... See more keywords
Tuberculosis: current scenario, drug targets, and future prospects
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02691-5
Abstract: Globally recognized genetic modification with time has supported the emergence of versatile and novel featured organisms in nature, some of which can be analogized with Pandora’s box elements; like Mycobacterium sp. which has revived itself… read more here.
Keywords: drug targets; targets future; drug; tuberculosis current ... See more keywords
In search for biomarkers and potential drug targets for uterine serous endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03566-x
Abstract: Serous endometrial cancer (USC) is a challenging malignancy associated with metastasis, recurrence and poor outcome. To identify clinically relevant prognostic biomarkers, we focused on a panel of proteins selected after a comprehensive literature review, for… read more here.
Keywords: drug targets; biomarkers potential; endometrial cancer; potential drug ... See more keywords
An overview of biochemically characterized drug targets in metabolic pathways of Leishmania parasite
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06736-x
Abstract: Leishmaniasis is a neglected tropical disease with no effective vaccines to date. Globally, it affects around 14 million people living in undeveloped and developing countries. Leishmania, which is the causative eukaryotic organism, possesses unique enzymes… read more here.
Keywords: drug targets; metabolic pathways; characterized drug; drug ... See more keywords
Inflammatory and Oxidative Pathways Are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes Are Additional Drug Targets in First Episode Schizophrenia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02343-8
Abstract: Breakdown of paracellular and vascular pathways and activated neuroimmune and oxidative pathways was established in (deficit) schizophrenia. The aim of this study was to delineate (a) the differences in these pathways between stable-phase, first (FES)… read more here.
Keywords: drug targets; schizophrenia; pneumoniae; c1q ... See more keywords
Drug targets for COVID-19 therapeutics: Ongoing global efforts
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00067-w
Abstract: The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to the human lives and global economy. There is an immediate need for identification of effective drugs to contain… read more here.
Keywords: targets covid; drug targets; drug; global efforts ... See more keywords
Proteases from dengue, West Nile and Zika viruses as drug targets
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00508-3
Abstract: Proteases from flaviviruses have gained substantial interest as potential drug targets to combat infectious diseases caused by dengue, West Nile, Zika and related viruses. Despite nearly two decades of drug discovery campaigns, promising lead compounds… read more here.
Keywords: drug targets; proteases dengue; drug; west nile ... See more keywords
Genetic Polymorphisms in Sepsis and Cardiovascular Disease: Do Similar Risk Genes Suggest Similar Drug Targets?
Sign Up to like & getrecommendations! Published in 2019 at "Chest"
DOI: 10.1016/j.chest.2019.01.003
Abstract: Genetic variants are associated with altered clinical outcome of patients with sepsis and cardiovascular diseases. Common gene signaling pathways may be involved in the pathophysiology of these diseases. A better understanding of genetic commonality among… read more here.
Keywords: sepsis cardiovascular; drug targets; cardiovascular disease;
Understanding drug targets: no such thing as bad news.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.028
Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated… read more here.
Keywords: drug targets; targets thing; thing bad; bad news ... See more keywords
Validation strategies for identifying drug targets in dermal fibrotic disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.06.014
Abstract: Fibrotic skin disorders, such as keloid disease (KD), are common clinically challenging disorders with unknown etiopathogenesis and ill-defined treatment strategies that affect millions of people worldwide. Thus, there is an urgent need to discover novel… read more here.
Keywords: drug targets; strategies identifying; dermal fibrotic; drug ... See more keywords
Target acquired: transcriptional regulators as drug targets for protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.12.007
Abstract: Protozoan parasites are single-celled eukaryotic organisms that cause significant human disease and pose a substantial health and socioeconomic burden worldwide. They are responsible for at least 1 million deaths annually. The treatment of such diseases… read more here.
Keywords: drug targets; protozoan parasites; transcriptional regulators; target acquired ... See more keywords