FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202201477
Abstract: Advancements in lab‐on‐a‐chip technologies have revolutionized the single‐cell analysis field. However, an accessible platform for in‐depth screening and specific retrieval of single cells, which moreover enables studying diverse cell types and performing various downstream analyses,… read more here.
Keywords: cell; platform; drug tolerance; microfluidic platform ... See more keywords
Inventory of ABC proteins and their putative role in salt and drug tolerance in Debaryomyces hansenii.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.029
Abstract: ATP-binding cassette (ABC) is one of the largest superfamily of proteins, which are ubiquitously present, performing variety of cellular functions. These proteins as drug transporters have been enticing substantial consideration because of their clinical importance.… read more here.
Keywords: abc proteins; drug; drug tolerance; salt drug ... See more keywords
A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2017.06.002
Abstract: We developed a homogeneous bridging anti-drug antibody (ADA) assay on an electro chemiluminescent immunoassay (ECLIA) platform to support the immunogenicity evaluation of a dimeric domain antibody (dAb) therapeutic in clinical studies. During method development we… read more here.
Keywords: treatment; method; drug; drug tolerance ... See more keywords
Dose-dependence in acquisition of drug tolerant phenotype and high RYK expression as a mechanism of osimertinib tolerance in lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.02.017
Abstract: OBJECTIVE Emergence of acquired resistance is almost inevitable during EGFR-tyrosine kinase inhibitor therapy for non-small-cell lung cancer (NSCLC) harboring EGFR mutations. Drug tolerance, a reversible state of drug insensitivity in the early phases of tyrosine… read more here.
Keywords: tolerance; drug; drug tolerance; lung cancer ... See more keywords
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27847-8
Abstract: Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. While prescribed as an inhibitor of… read more here.
Keywords: cancer; drug tolerance; cancer cell; drug ... See more keywords
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Sign Up to like & getrecommendations! Published in 2022 at "Nature microbiology"
DOI: 10.1038/s41564-022-01072-5
Abstract: Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs for amino acid biosynthesis pathways in microbiome data derived from >12,000 natural microbial… read more here.
Keywords: drug tolerance; drug; communities form; microbial communities ... See more keywords
Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes
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DOI: 10.1128/mbio.00227-23
Abstract: Antifungal drug tolerance differs from drug resistance: tolerant cells grow slowly in drug, while resistant cells usually grow well, due to mutations in a few known genes. More than half of Candida albicans clinical isolates… read more here.
Keywords: drug tolerance; physiology; drug concentrations; resistance ... See more keywords
Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance
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DOI: 10.1128/mbio.02795-22
Abstract: Tuberculosis is unusual among bacterial diseases in that treatments which can rapidly resolve symptoms do not predictably lead to a durable cure unless treatment is continued for months after all clinical and microbiological signs of… read more here.
Keywords: drug tolerance; mycobacterium tuberculosis; drug; resistance ... See more keywords
The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03559-21
Abstract: Understanding the mechanisms underlying M. tuberculosis adaptive strategies to achieve drug tolerance is crucial for the identification of new targets and the development of new drugs. Here, we show that acetate medium triggers a drug-tolerant… read more here.
Keywords: drug tolerance; drug; tuberculosis; state ... See more keywords
Abstract P6-03-04: Microenvironment-induced epigenetic reprogramming imposes drug-tolerant states in breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p6-03-04
Abstract: Development of resistance to breast cancer (BC) therapy is frustratingly common. Multiple mechanisms of resistance have been identified including selection of genetic resistance, redundant signaling, and others. More recently, rare cancer cells were shown to… read more here.
Keywords: drug; cancer cells; cancer; breast cancer ... See more keywords
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell"
DOI: 10.15698/mic2022.05.777
Abstract: Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host's fatty acids as a main carbon source… read more here.
Keywords: acid metabolism; mycobacterium tuberculosis; fatty acid; drug tolerance ... See more keywords