Cancer Drug Toxicity: Moving from Patient to Survivor.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer treatment and research"
DOI: 10.1007/978-3-319-43896-2_8
Abstract: Millions of individuals worldwide are living with cancer and have remained disease-free for more than 5 years. These individuals are considered to be cancer survivors. The advent of new targeted therapies and personalized treatment modalities… read more here.
Keywords: toxicity moving; survivorship; cancer; drug toxicity ... See more keywords
B2FSE framework for high dimensional imbalanced data: A case study for drug toxicity prediction
Sign Up to like & getrecommendations! Published in 2018 at "Neurocomputing"
DOI: 10.1016/j.neucom.2017.04.081
Abstract: Abstract The life of people is imperiled by umpteen chemicals unwittingly through the diverse sources like food, cleaning products, medicines, etc. At times, these chemicals can be toxic. Assessing and analyzing the toxicity of these… read more here.
Keywords: framework; toxicity; b2fse framework; drug toxicity ... See more keywords
Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.05.004
Abstract: Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues, a co-culture of primary human… read more here.
Keywords: inflammation associated; inflammation; toxicity; model ... See more keywords
Artificial Intelligence in Drug Toxicity Prediction: Recent Advances, Challenges, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00200
Abstract: Toxicity prediction is a critical step in the drug discovery process that helps identify and prioritize compounds with the greatest potential for safe and effective use in humans, while also reducing the risk of costly… read more here.
Keywords: artificial intelligence; toxicity prediction; toxicity; drug toxicity ... See more keywords
Online Analysis of Drug Toxicity to Cells with Shear Stress on an Integrated Microfluidic Chip.
Sign Up to like & getrecommendations! Published in 2019 at "ACS sensors"
DOI: 10.1021/acssensors.8b01696
Abstract: Mechanical stimulation, especially fluid shear stress (FSS), is essential for a cell to regulate regular behaviors. A high-throughput platform to provide varying FSS for cell research is desperately required for better mimicking of the complex… read more here.
Keywords: integrated microfluidic; shear stress; toxicity; drug ... See more keywords
Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08978j
Abstract: We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug… read more here.
Keywords: drug; drug toxicity; potent cytotoxic; cytotoxic therapeutics ... See more keywords
Severity of emergency department presentations due to acute drug toxicity in Europe: a longitudinal analysis over a 6-year period (2014–2019) stratified by sex
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Emergency Medicine"
DOI: 10.1097/mej.0000000000000978
Abstract: Objective To investigate whether the severity of acute recreation drug toxicity presentations to emergency departments (EDs) in Europe has changed in recent years and to uncover potential sex differences. Design We analysed presentations to 36… read more here.
Keywords: drug toxicity; death; analysis; sex ... See more keywords
Nanocarrier-Based Tumor-Targeting Drug Delivery Systems for Hepatocellular Carcinoma Treatments: Enhanced Therapeutic Efficacy and Reduced Drug Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3297
Abstract: Hepatocellular carcinoma (HCC), due to the lack of efficient diagnostic methods and short of available treatments, becomes the third main cause of cancer deaths. Novel treatments for HCCs are thus in great need. The fast-growing… read more here.
Keywords: hepatocellular carcinoma; drug toxicity; delivery systems; drug delivery ... See more keywords