A Magnetically Driven Amoeba‐Like Nanorobot for Whole‐Process Active Drug Transport
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204793
Abstract: The passive diffusion performance of nanocarriers results in inefficient drug transport across multiple biological barriers and consequently cancer therapy failure. Here, a magnetically driven amoeba‐like nanorobot (amNR) is presented for whole‐process active drug transport. The… read more here.
Keywords: whole process; magnetically driven; process active; drug transport ... See more keywords
On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.2946
Abstract: Generating anatomically realistic 3-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic images used for 3D reconstructions typically exclude… read more here.
Keywords: fluid dynamics; transport; nozzle subtraction; vestibular dilation ... See more keywords
Computational modeling of drug transport across the in vitro cornea
Sign Up to like & getrecommendations! Published in 2018 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2017.11.009
Abstract: A novel quasi-3D (Q3D) modeling approach was developed to model networks of one dimensional structures like tubes and vessels common in human anatomy such as vascular and lymphatic systems, neural networks, and respiratory airways. Instead… read more here.
Keywords: cornea; computational modeling; transport across; drug ... See more keywords
A wettability-based approach for the monitoring of drug transport through biological membranes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2019.07.111
Abstract: The aim of the work was to exploit a methodology based on contact angle measurements for the purpose of membrane transport studies. Special attention has been paid to a model system of pharmacological relevance, consisting… read more here.
Keywords: surface; transport; drug; drug transport ... See more keywords
How does stent expansion alter drug transport properties of the arterial wall?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2019.103610
Abstract: Stents have become the most successful device to treat advanced atherosclerotic lesions. However, one of the main issues with these interventions is the development of restenosis. The coating of stents with antiproliferative substances to reduce… read more here.
Keywords: drug; transport properties; arterial wall; drug transport ... See more keywords
Applications of Synthetic Receptors in Bioanalysis and Drug Transport.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00096
Abstract: Synthetic receptors are powerful tools for molecular recognition. They can bind to guests with high selectivity and affinity, and their structures are tunable and diversified. These features, plus the relatively low cost and high simplicity… read more here.
Keywords: applications synthetic; drug transport; synthetic receptors; receptors bioanalysis ... See more keywords
Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.965200
Abstract: Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such mechanistic insights by… read more here.
Keywords: barrier; transport biologics; across intestinal; transport ... See more keywords
Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein (BCRP)
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020166
Abstract: During pregnancy, the placenta is established as a primary organ for drug transport at the maternal-fetal interface. The fetal membranes (FM) also form an interface with maternal tissues; however, their role in drug transport has… read more here.
Keywords: bcrp; transport; across feto; resistance ... See more keywords
Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12010069
Abstract: Focused ultrasound (FUS) coupled with microbubbles (MB) has been found to be a promising approach to disrupt the blood-brain barrier (BBB). However, how this disruption affects drug transport remains unclear. In this study, drug transport… read more here.
Keywords: focused ultrasound; study; drug; drug transport ... See more keywords
Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112522
Abstract: One of the current trends in modern pharmaceuticals is the supply of drugs by transport systems. The use of delivery systems allows to increase the therapeutic efficacy, tolerability, and safety of drug therapy. Liposomes, polymer… read more here.
Keywords: phospholipid nanoparticles; transport system; technology; drug transport ... See more keywords