Use of a Caco-2 permeability assay to evaluate the effects of several Kampo medicines on the drug transporter P-glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1222-x
Abstract: In modern medical care in which Kampo and Western drugs are often combined, it is extremely important to clarify drug–drug interaction (DDI) to ensure safety and efficacy. However, there is little evidence of DDI in… read more here.
Keywords: five kampo; kampo medicines; drug; transporter glycoprotein ... See more keywords
Research and development of drug delivery systems based on drug transporter and nano-formulation
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2020.02.004
Abstract: In recent years, the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter. Changes in the expression and activity of transporters can cause corresponding changes in drug… read more here.
Keywords: drug; drug transporter; nano formulation; development ... See more keywords
UPDATE ON DRUG TRANSPORTER PROTEINS IN ACUTE MYELOID LEUKEMIA: PATHOLOGICAL IMPLICATION AND CLINICAL SETTING.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103281
Abstract: Acute myeloid leukemia (AML) is one of the most common hematological neoplasia causing death worldwide. The long-term overall survival is unsatisfactory due to many factors including older age, genetic heterogeneity and molecular characteristics comprising additional… read more here.
Keywords: transporter proteins; myeloid leukemia; drug transporter; acute myeloid ... See more keywords
Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2020.09.003
Abstract: Drug transporters play important roles in the elimination of various compounds from the blood. Genetic variation and drug-drug interactions underlie the pharmacokinetic differences for the substrates of drug transporters. Some endogenous substrates of drug transporters… read more here.
Keywords: progress identifying; drug; drug transporter; current progress ... See more keywords
VARIDT 2.0: structural variability of drug transporter.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab1013
Abstract: The structural variability data of drug transporter (DT) are key for research on precision medicine and rational drug use. However, these valuable data are not sufficiently covered by the available databases. In this study, a… read more here.
Keywords: structural variability; variability; drug; drug transporter ... See more keywords
Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082750
Abstract: Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities. Current in vitro systems poorly represent physiology, with reduced… read more here.
Keywords: drug; microphysiological systems; physiology; drug transporter ... See more keywords
Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes
Sign Up to like & getrecommendations! Published in 2018 at "Human Genomics"
DOI: 10.1186/s40246-018-0175-1
Abstract: BackgroundGenetic polymorphisms can contribute to phenotypic differences amongst individuals, including disease risk and drug response. Characterization of genetic polymorphisms that modulate gene expression and/or protein function may facilitate the identification of the causal variants. Here,… read more here.
Keywords: polymorphisms human; response; human genome; transporter genes ... See more keywords