Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2594
Abstract: Abrocitinib is an oral Janus kinase 1 (JAK1) inhibitor currently approved in the United Kingdom for the treatment of moderate‐to‐severe atopic dermatitis (AD). As patients with AD may use medications to manage comorbidities, abrocitinib could… read more here.
Keywords: effect abrocitinib; drugs endogenous; drug transporters; exposure ... See more keywords
Implication of human drug transporters to toxicokinetics and toxicity of pesticides.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5577
Abstract: Human membrane drug transporters are recognized as major actors of pharmacokinetics. Pesticides also interact with human drug transporters, which may have consequences for pesticide toxicokinetics and toxicity. The present review summarizes key-findings about this topic.… read more here.
Keywords: pesticide; toxicokinetics toxicity; drug; drug transporters ... See more keywords
Contributions of Drug Transporters to Blood-Brain Barriers.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7647-4_9
Abstract: Blood-brain interfaces comprise the cerebral microvessel endothelium forming the blood-brain barrier (BBB) and the epithelium of the choroid plexuses forming the blood-cerebrospinal fluid barrier (BCSFB). Their main functions are to impede free diffusion between brain… read more here.
Keywords: blood brain; transporters blood; contributions drug; brain ... See more keywords
Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.01.001
Abstract: Antibiotics act on bacterial flora originally present in the intestine, and changes in the intestinal flora have various effects on the host. This study investigated changes in the protein levels of drug transporters and metabolizing… read more here.
Keywords: antibiotic treated; transporters metabolizing; drug; metabolizing enzymes ... See more keywords
Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease.
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DOI: 10.1021/acs.molpharmaceut.8b00500
Abstract: Drug transporter expression and function at the blood-brain barrier is altered in Alzheimer's disease (AD). However, the impact of AD on the expression of transporters and metabolizing enzymes in peripheral tissues has received little attention.… read more here.
Keywords: alzheimer disease; drug; expression; mouse model ... See more keywords
Expression and regulation of drug transporters in vertebrate neutrophils
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DOI: 10.1038/s41598-017-04785-4
Abstract: There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs… read more here.
Keywords: regulation drug; transporters vertebrate; drug; drug transporters ... See more keywords
In vitro assessment of the roles of drug transporters in the disposition and drug–drug interaction potential of olaparib
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1241449
Abstract: Abstract 1. In vitro assessments were conducted to examine interactions between olaparib (a potent oral inhibitor of poly[ADP-ribose] polymerase) and drug transporters. 2. Olaparib showed inhibition of the hepatic drug uptake transporters OATP1B1 (IC50 values of 20.3 μM… read more here.
Keywords: limited inhibition; inhibition; drug; olaparib ... See more keywords
Genetic Diversity in Drug Transporters: Impact in African Populations
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DOI: 10.1111/cts.12769
Abstract: Polymorphisms in drug transporters, like the adenosine triposphate‒binding cassette (ABC) and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug response in African patients. This review aims to provide a comprehensive summary… read more here.
Keywords: genetic diversity; diversity drug; drug; drug transporters ... See more keywords
Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.085647
Abstract: Rhinacanthin-C is a major active constituent in Rhinacanthus nasutus (L.) Kurz, a plant widely used in herbal remedies. Its potential for pharmacokinetic herb-drug interaction may exist with drug transporters and drug metabolizing enzymes. This study… read more here.
Keywords: drug metabolizing; drug interaction; drug; ic50 ... See more keywords
Transcriptional Regulation of Solute Carrier Drug Transporters
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DOI: 10.1124/dmd.121.000704
Abstract: Facilitated transport is necessitated for large size, charged, and/or hydrophilic drugs to move across the membrane. The drug transporters in the solute carrier (SLC) superfamily, mainly including organic anion-transporting polypeptides, organic anion transporters, organic cation… read more here.
Keywords: transcriptional regulation; drug; drug transporters; solute carrier ... See more keywords
Effect of Genetic Variations in Drug-Metabolizing Enzymes and Drug Transporters on the Pharmacokinetics of Rifamycins: A Systematic Review
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DOI: 10.2147/pgpm.s363058
Abstract: Abstract Background Rifamycins are a novel class of antibiotics clinically approved for tuberculosis chemotherapy. They are characterized by high inter-individual variation in pharmacokinetics. This systematic review aims to present the contribution of genetic variations in… read more here.
Keywords: drug transporters; systematic review; drug metabolizing; genetic variations ... See more keywords