Multimodal Vibrational Studies Of Drug Uptake In Vitro: Is The Whole Greater Than The Sum Of Their Parts?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biophotonics"
DOI: 10.1002/jbio.202000264
Abstract: Herein, we investigated the use of multimodal Raman and infrared (IR) spectroscopic microscopy for the elucidation of drug uptake and subsequent cellular responses. Firstly, we compared different methods for the analysis of the combined data.… read more here.
Keywords: raman; analysis; vibrational studies; multimodal vibrational ... See more keywords
Measurement of three-dimensional distributions of drugs in nails using liquid chromatography/tandem mass spectrometry after micro-segmentation to elucidate drug uptake routes.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.02.050
Abstract: Ingested drugs can be taken up into nails and hairs from the bloodstream and these drugs can be stably retained over several months or more. Free edges of nails can often be used as a… read more here.
Keywords: three dimensional; uptake routes; drug; drugs nails ... See more keywords
Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39770-6
Abstract: Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age… read more here.
Keywords: epidermal differentiation; differentiation drug; differentiation; homeostasis epidermal ... See more keywords
Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s188791
Abstract: Purpose Modulated electro-hyperthermia (mEHT) stands to be a significant technological advancement in the hyperthermia field, utilizing autofocusing electromagnetic power on the cell membrane to create massive apoptosis. Since mEHT possesses the unique ability to excite… read more here.
Keywords: cancer cells; meht; hyperthermia; drug uptake ... See more keywords
Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells [Corrigendum]
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s207678
Abstract: On page 1273 in Results section, the following sentence was presented incorrectly: “Therefore, we can confirm that the cytotoxic enhancement of mEHT plus Lipodox® was due to increased release of doxorubicin in medium.” It should… read more here.
Keywords: drug uptake; hyperthermia enhanced; electro hyperthermia; enhanced liposomal ... See more keywords
Design and Simulation of Microfluidic Device for Metabolite Screening and Quantitative Monitoring of Drug Uptake in Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Electrical Bioimpedance"
DOI: 10.2478/joeb-2018-0003
Abstract: Abstract Although liquid-liquid extraction methods are currently being applied in many areas such as analytical chemistry, biochemical engineering, biochemistry, and biological applications, accessibility and usability of microfluidics in practical daily life fields are still bounded.… read more here.
Keywords: uptake cancer; drug; cancer cells; cancer ... See more keywords
Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery
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DOI: 10.3390/pharmaceutics14050902
Abstract: Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence of hypoxic tumor cells impedes drug uptake and reduces the cytotoxicity of chemotherapeutic drugs, leading to HDR and increasing the probability of… read more here.
Keywords: reoxygenation; drug uptake; hypoxia induced; hdr ... See more keywords
Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies
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DOI: 10.3390/pharmaceutics14122714
Abstract: The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents,… read more here.
Keywords: drug uptake; solubility; using absorption; absorption fluorescence ... See more keywords