LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "druggable target" as a keyword



FSCN1 as a new druggable target in adrenocortical carcinoma

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Cancer"

DOI: 10.1002/ijc.34526

Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatic spread. The actin‐bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has… read more here.

Keywords: new druggable; druggable target; acc; adrenocortical carcinoma ... See more keywords
Photo by impulsq from unsplash

KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures.

Sign Up to like & get
recommendations! Published in 2020 at "Cancer treatment reviews"

DOI: 10.1016/j.ctrv.2020.101978

Abstract: Cancers of nearly all lineages harbor alterations that deregulate mitogen-activated protein kinase signaling, a crucial signaling pathway for tumor formation and maintenance. Of these, KRAS mutations are the most frequent gain-of-function alterations found in patients… read more here.

Keywords: nsclc rising; target; kras druggable; druggable target ... See more keywords

Abstract 3673: Identifying druggable target in medulloblastoma

Sign Up to like & get
recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-3673

Abstract: Approximately 15, 000 children in the United States are diagnosed with cancer annually. While pediatric cancers boast a 10-year survival rate of approximately 80%, they present unique challenges in drug discovery due to the low… read more here.

Keywords: cancer; target medulloblastoma; identifying druggable; abstract 3673 ... See more keywords

A Promising Druggable Target for Translational Therapy of Ovarian Cancer: A Molecular Profiling of Therapeutic Innovations, Extracellular Vesicle Acquired Resistance, and Signaling Pathways.

Sign Up to like & get
recommendations! Published in 2025 at "Current medicinal chemistry"

DOI: 10.2174/0109298673331849240930140120

Abstract: Ovarian cancer (OC) ranks as the fifth leading cause of cancer-related deaths in the United States, posing a significant threat to female health. Late-stage diagnoses, driven by elusive symptoms often masquerading as gastrointestinal issues, contribute… read more here.

Keywords: cancer; signaling pathways; promising druggable; ovarian cancer ... See more keywords

Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2022.1071929

Abstract: Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel… read more here.

Keywords: kcal mol; druggable target; fibroblast growth; growth factor ... See more keywords

NF-κB: A Druggable Target in Acute Myeloid Leukemia

Sign Up to like & get
recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14143557

Abstract: Simple Summary AML is a highly heterogeneous hematological disease and is the second most common form of leukemia. Around 40% of AML patients display elevated nuclear NF-κB activity, providing a compelling rationale for targeting the… read more here.

Keywords: myeloid leukemia; aml patients; aml; druggable target ... See more keywords
Photo from wikipedia

KRAS: A Druggable Target in Colon Cancer Patients

Sign Up to like & get
recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23084120

Abstract: Mutations in KRAS are among the most frequent aberrations in cancer, including colon cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule inhibition. Moreover, its elevated affinity to cellular guanosine… read more here.

Keywords: target colon; druggable target; kras druggable; cancer ... See more keywords

DLC1 as Druggable Target for Specific Subsets of Gastric Cancer: An RNA-seq-Based Study

Sign Up to like & get
recommendations! Published in 2023 at "Medicina"

DOI: 10.3390/medicina59030514

Abstract: Background: Gastric cancer has been ranked the third leading cause of cancer death worldwide. Its detection at the early stage is difficult because patients mostly experience vague and non-specific symptoms in the early stages. Methods:… read more here.

Keywords: specific subsets; druggable target; rna seq; target specific ... See more keywords