FSCN1 as a new druggable target in adrenocortical carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34526
Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatic spread. The actin‐bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has… read more here.
Keywords: new druggable; druggable target; acc; adrenocortical carcinoma ... See more keywords
KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2020.101978
Abstract: Cancers of nearly all lineages harbor alterations that deregulate mitogen-activated protein kinase signaling, a crucial signaling pathway for tumor formation and maintenance. Of these, KRAS mutations are the most frequent gain-of-function alterations found in patients… read more here.
Keywords: nsclc rising; target; kras druggable; druggable target ... See more keywords
Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1071929
Abstract: Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel… read more here.
Keywords: kcal mol; druggable target; fibroblast growth; growth factor ... See more keywords
NF-κB: A Druggable Target in Acute Myeloid Leukemia
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DOI: 10.3390/cancers14143557
Abstract: Simple Summary AML is a highly heterogeneous hematological disease and is the second most common form of leukemia. Around 40% of AML patients display elevated nuclear NF-κB activity, providing a compelling rationale for targeting the… read more here.
Keywords: myeloid leukemia; aml patients; aml; druggable target ... See more keywords
KRAS: A Druggable Target in Colon Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084120
Abstract: Mutations in KRAS are among the most frequent aberrations in cancer, including colon cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule inhibition. Moreover, its elevated affinity to cellular guanosine… read more here.
Keywords: target colon; druggable target; kras druggable; cancer ... See more keywords
DLC1 as Druggable Target for Specific Subsets of Gastric Cancer: An RNA-seq-Based Study
Sign Up to like & getrecommendations! Published in 2023 at "Medicina"
DOI: 10.3390/medicina59030514
Abstract: Background: Gastric cancer has been ranked the third leading cause of cancer death worldwide. Its detection at the early stage is difficult because patients mostly experience vague and non-specific symptoms in the early stages. Methods:… read more here.
Keywords: specific subsets; druggable target; rna seq; target specific ... See more keywords