Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21709
Abstract: Coronavirus disease‐19 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is one of the most contagious diseases in human history that has already affected millions of lives worldwide. To date, no vaccines or… read more here.
Keywords: druggable targets; drug; clinical trials; review ... See more keywords
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20721-6
Abstract: Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to… read more here.
Keywords: risk; druggable targets; coronary artery; artery disease ... See more keywords
ST2 and CSF‐1 as potential druggable targets of inflammatory bowel diseases: Results from two‐sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13442
Abstract: Novel druggable targets are warranted for inflammatory bowel disease (IBD) treatment. We aimed to identify novel circulating proteins with causal associations with the risk of IBDs and provide potential therapeutic targets for IBD treatment. We… read more here.
Keywords: two sample; sample mendelian; mendelian randomization; inflammatory bowel ... See more keywords
Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s189661
Abstract: Background: Gastrointestinal stromal tumors (GISTs) represent a worldwide paradigm of target therapy. The introduction of tyrosine kinase inhibitors has deeply changed the prognosis of GIST patients, however, the majority of them acquire secondary mutations and… read more here.
Keywords: stromal tumors; druggable targets; identify novel; pi3k inhibitor ... See more keywords
New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.834247
Abstract: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease characterized by chronic inflammation and destruction of multiple small joints which may lead to systemic complications. Altered immunity via pathogenic autoantibodies pre-date clinical symptom development by several… read more here.
Keywords: new druggable; rheumatoid arthritis; synovial biology; druggable targets ... See more keywords
Mitochondrial Potassium Channels as Druggable Targets
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10081200
Abstract: Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have cytoprotective effects in… read more here.
Keywords: mitochondrial potassium; potassium channels; potassium; druggable targets ... See more keywords
Intestinal Enteroendocrine Cells: Present and Future Druggable Targets
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108836
Abstract: Enteroendocrine cells are specialized secretory lineage cells in the small and large intestines that secrete hormones and peptides in response to luminal contents. The various hormones and peptides can act upon neighboring cells and as… read more here.
Keywords: cells present; enteroendocrine cells; present future; intestinal enteroendocrine ... See more keywords
Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070892
Abstract: Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have shared mediators, overlapping neural circuitry, and similarities in sensitization processes.… read more here.
Keywords: antinociceptive antipruritic; antipruritic effects; pain itch; druggable targets ... See more keywords
Potential Targeted Therapies in Ovarian Cancer
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DOI: 10.3390/ph15111324
Abstract: Background: We aimed to identify somatic pathogenic and likely pathogenic mutations using next-generation sequencing (NGS). The mutational findings were held against clinically well-described data to identify potential targeted therapies in Danish patients diagnosed with high-grade… read more here.
Keywords: potential targeted; targeted therapies; ovarian cancer; platinum sensitive ... See more keywords