Drugging the undruggable proteins in cancer: A systems biology approach.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.07.004
Abstract: In recent years, the research community has, with comprehensive systems biology approaches and related technologies, gained insight into the vast complexity of numerous cancers. These approaches allow an in-depth exploration that cannot be achieved solely… read more here.
Keywords: proteins cancer; drugging undruggable; biology; systems biology ... See more keywords
Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
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DOI: 10.1158/0008-5472.can-20-3108
Abstract: Effective treatment of pediatric solid tumors has been hampered by the predominance of currently “undruggable” driver transcription factors. Improving outcomes while decreasing the toxicity of treatment necessitates the development of novel agents that can directly… read more here.
Keywords: transcription; undruggable mycn; transcription factor; mycn ... See more keywords