Screening approach for identifying candidate drugs and drug‐drug interactions related to hip fracture risk in persons with Alzheimer disease
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DOI: 10.1002/pds.4232
Abstract: To assess whether a “drugome‐wide” screen with case‐crossover design is a feasible approach for identifying candidate drugs and drug‐drug interactions. read more here.
Keywords: candidate drugs; approach identifying; identifying candidate; drug ... See more keywords
Targeting TDP‐43 proteinopathy with drugs and drug‐like small molecules
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DOI: 10.1111/bph.15148
Abstract: Following the discovery of the involvement of the ribonucleoprotein TDP‐43 in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research focus has been to develop treatments that can prevent or alleviate these… read more here.
Keywords: drugs drug; proteinopathy drugs; tdp; small molecules ... See more keywords
Enantioselective Drug Recognition by Drug Transporters
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DOI: 10.3390/molecules23123062
Abstract: Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton-coupled folate transporters (PCFT/SLC46A1), organic anion transporting polypeptides… read more here.
Keywords: enantioselective drug; drug; drug recognition; drugs drug ... See more keywords
Noncoding RNAs Emerging as Drugs or Drug Targets: Their Chemical Modification, Bio-Conjugation and Intracellular Regulation
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DOI: 10.3390/molecules27196717
Abstract: With the increasing understanding of various disease-related noncoding RNAs, ncRNAs are emerging as novel drugs and drug targets. Nucleic acid drugs based on different types of noncoding RNAs have been designed and tested. Chemical modification… read more here.
Keywords: rnas emerging; drugs drug; noncoding rnas; drug ... See more keywords