Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2594
Abstract: Abrocitinib is an oral Janus kinase 1 (JAK1) inhibitor currently approved in the United Kingdom for the treatment of moderate‐to‐severe atopic dermatitis (AD). As patients with AD may use medications to manage comorbidities, abrocitinib could… read more here.
Keywords: effect abrocitinib; drugs endogenous; drug transporters; exposure ... See more keywords
Structural Biology of Human GPCR Drugs and Endogenous Ligands - Insights from NMR Spectroscopy.
Sign Up to like & getrecommendations! Published in 2020 at "Methods"
DOI: 10.1016/j.ymeth.2020.08.008
Abstract: G protein-coupled receptors (GPCRs) represent the largest class of "druggable" proteins in the human genome. For more than a decade, crystal structures and, more recently, cryoEM structures of GPCR complexes have provided unprecedented insight into… read more here.
Keywords: endogenous ligands; structural biology; nmr spectroscopy; biology ... See more keywords