Glucose-Lowering Drugs and Fracture Risk—a Systematic Review
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DOI: 10.1007/s11914-020-00638-8
Abstract: Diabetes mellitus (DM) is associated with increased fracture risk. The aim of this systematic review was to examine the effects of different classes of glucose-lowering drugs on fracture risk in patients with type 2 DM.… read more here.
Keywords: drugs fracture; fracture; lowering drugs; fracture risk ... See more keywords
Association of antihypertensive drugs with fracture and bone mineral density: A comprehensive drug-target Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1164387
Abstract: Background Observational studies have investigated the associations between antihypertensive drugs and fracture risk as well as bone mineral density (BMD), but yielding controversial results. Methods In this study, a comprehensive drug-target Mendelian randomization (MR) analysis… read more here.
Keywords: mineral density; bmd; genetic proxies; bone mineral ... See more keywords
Rethinking the Appraisal and Approval of Drugs for Fracture Prevention
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00265
Abstract: Background: In January 2014, the EMA's Pharmacovigilance Risk Assessment Committee recommended that strontium ranelate no longer be used for osteoporosis. However, EMA's Committee for Medicinal Products for Human Use decided to restrict its use rather… read more here.
Keywords: fracture prevention; drugs fracture; harm benefit; rethinking appraisal ... See more keywords