Articles with "drugs future" as a keyword



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Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future

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Published in 2022 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.122.000860

Abstract: Xenobiotic receptors, such as the pregnane X receptor, regulate multiple host physiologic pathways including xenobiotic metabolism, certain aspects of cellular metabolism, and innate immunity. These ligand-dependent nuclear factors regulate gene expression via genomic recognition of… read more here.

Keywords: drugs future; metabolism; metabolites ligands; microbial metabolites ... See more keywords
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From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23031075

Abstract: This review comprehensively describes the recent advances in the synthesis and pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins, claramine, and their diverse analogs and derivatives, with a special focus on their complete synthesis from… read more here.

Keywords: squalamine trodusquemine; drugs future; marine metabolites; trodusquemine steroid ... See more keywords