Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34677-0
Abstract: The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted… read more here.
Keywords: regions chemical; drugs holistic; scaffold hopping; chemical space ... See more keywords
The holistic approach to psoriasis patients with comorbidities: the role of investigational drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on investigational drugs"
DOI: 10.1080/13543784.2023.2219387
Abstract: INTRODUCTION Psoriasis is a high-burden syndrome characterized by cutaneous and extracutaneous manifestations that profoundly reduce patients' quality of life. The presence of concomitant comorbidities often represents a limit to the most appropriate psoriasis treatment that… read more here.
Keywords: investigational drugs; role; approach psoriasis; drugs holistic ... See more keywords