Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109133
Abstract: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed ten hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2… read more here.
Keywords: inhibit sars; protease; drugs inhibit; sars cov ... See more keywords
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03491-6
Abstract: COVID-19 is a disease with unique characteristics including lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar oedema4. The pathological substrate for these findings remains… read more here.
Keywords: syncytia; cov spike; inhibit tmem16; drugs inhibit ... See more keywords
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo5400
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic COVID-19 in most cases, but some patients develop an excessive inflammatory process that can be fatal. As the NLRP3 inflammasome and additional inflammasomes are… read more here.
Keywords: drugs inhibit; identification immunomodulatory; immunomodulatory drugs; cov infection ... See more keywords
Abstract 2795: Screening and characterization of drugs that inhibit the ubiquitin-proteasome system
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2795
Abstract: Pharmacological inhibition of proteasomal cysteine deubiquitinase (DUB) activity (i.e., USP14 and UCHL5 DUBs) has been shown to be particularly cytotoxic to cancer cells and to result in inhibition of tumor growth in several in vivo… read more here.
Keywords: hit compounds; proteasome; screening characterization; characterization drugs ... See more keywords
Small Molecule Drugs That Inhibit Phagocytosis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020757
Abstract: In our initial publication on the in vitro testing of more than 200 compounds, we demonstrated that small molecules can inhibit phagocytosis. We therefore theorized that a small molecule drug discovery-based approach to the treatment… read more here.
Keywords: small molecule; drugs inhibit; inhibit phagocytosis; phagocytosis ... See more keywords