Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors
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DOI: 10.1038/s41388-019-0965-5
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency… read more here.
Keywords: drugs mtor; topoisomerase targeted; dna topoisomerase; nerve sheath ... See more keywords