Drugs targeting intermediate filaments can improve neurosupportive properties of astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.01.021
Abstract: In response to central nervous system (CNS) injury, astrocytes upregulate intermediate filament (nanofilament) proteins GFAP and vimentin. Whereas the intermediate filament upregulation in astrocytes is important for neuroprotection in the acute phase of injury, in… read more here.
Keywords: drugs targeting; clomipramine epoxomicin; targeting intermediate; neurosupportive properties ... See more keywords
The study of antiviral drugs targeting SARS-CoV-2 nucleocapsid and spike proteins through large-scale compound repurposing
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06387
Abstract: Contributing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clinical treatment, a drug library encompassing approximately 3,142 clinical-stage or FDA-approved small molecules is profiled to identify the candidate therapeutic inhibitors targeting nucleocapsid protein (N) and… read more here.
Keywords: protein; domain protein; drugs targeting; antiviral drugs ... See more keywords
Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00144
Abstract: The restricted pipeline of drugs targeting the liver stage of Plasmodium infection reflects the scarcity of cell models that mimic the human hepatic phenotype and drug metabolism, as well as Plasmodium hepatic infection. Using stirred-tank… read more here.
Keywords: hepatic infection; drugs targeting; infection; plasmodium hepatic ... See more keywords
Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44887-9
Abstract: The influence of carbon metabolism on oxidative phosphorylation is poorly understood in mycobacteria. M. tuberculosis expresses two respiratory terminal oxidases, the cytochrome bc1:aa3 and the cytochrome bd oxidase, which are jointly required for oxidative phosphorylation… read more here.
Keywords: cytochrome bc1; drugs targeting; carbon metabolism; bc1 aa3 ... See more keywords
Repurposing anticancer drugs for targeting necroptosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1442626
Abstract: ABSTRACT Necroptosis represents a form of programmed cell death that can be engaged by various upstream signals, for example by ligation of death receptors, by viral sensors or by pattern recognition receptors. It depends on… read more here.
Keywords: targeting necroptosis; drugs targeting; necroptosis; drug ... See more keywords
Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2019.1664469
Abstract: ABSTRACT Introduction: G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins highly expressed in the brain that are involved in almost all functions of the CNS. During the last twenty years, a large number… read more here.
Keywords: based interactome; drugs targeting; receptor based; dopamine receptor ... See more keywords
Bioinformatics analysis of candidate genes and potential therapeutic drugs targeting adipose tissue in obesity
Sign Up to like & getrecommendations! Published in 2022 at "Adipocyte"
DOI: 10.1080/21623945.2021.2013406
Abstract: ABSTRACT Obesity is a complex medical condition that affects multiple organs in the body. However, the underlying mechanisms of obesity, as well as its treatment, are largely unexplored. The focus of this research was to… read more here.
Keywords: tissue; genes potential; obesity; potential therapeutic ... See more keywords
Repurposing of drugs targeting the cytokine storm induced by SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15987
Abstract: A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis‐associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The coronavirus… read more here.
Keywords: repurposing drugs; cytokine storm; sars cov; drugs targeting ... See more keywords
The ethics of disease-modifying drugs targeting Alzheimer disease: response to our commentators
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2022-108157
Abstract: In Gustavsson et al, we discussed the ethical issues that arise when identifying the relevant population for diseasemodifying drugs targeting Alzheimer disease (AD). More specifically, we focused on novel immunotherapies aimed at amyloid β and… read more here.
Keywords: aduhelm; targeting alzheimer; disease; drugs targeting ... See more keywords
Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0566
Abstract: Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins in the PI3K/AKT and MAPK… read more here.
Keywords: xenograft models; phosphorylation; mapk; pi3k ... See more keywords
The Future: Experimental Therapies for Renal Disease in Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Nephron"
DOI: 10.1159/000492825
Abstract: Diabetic nephropathy is the commonest cause of end-stage renal disease and affects between 30 and 45% of patients with diabetes mellitus. There is no cure for diabetic nephropathy and the current management of this condition… read more here.
Keywords: experimental therapies; renal disease; drugs targeting; disease ... See more keywords