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   Articles with "drv" as a keyword



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Validation of the novel Deep Reality Viewer (DRV) 3D digital stereo viewer in otology surgery

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recommendations! Published in 2022 at "European Archives of Oto-Rhino-Laryngology"

DOI: 10.1007/s00405-022-07305-x

Abstract: Magnification with accurate optic reproduction of the surgical field is essential in otology surgery, but current technologies are subject to specific disadvantages. This study aims to evaluate a novel 3D digital stereo viewer, the Deep… read more here.

Keywords: viewer; microscopy; otology surgery; otology ... See more keywords
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Virologic Outcomes Among ART-Naïve Individuals Initiating Dolutegravir, Elvitegravir, Raltegravir or Darunavir: An Observational Study

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recommendations! Published in 2019 at "Infectious Diseases and Therapy"

DOI: 10.1007/s40121-019-00274-5

Abstract: Introduction Dolutegravir (DTG), Elvitegravir (EVG), Raltegravir (RAL) and Darunavir (DRV) are commonly prescribed core agents for antiretroviral therapy (ART), and a need exists to compare their clinical effectiveness, as defined by virologic failure risks in… read more here.

Keywords: ral drv; dtg; virologic failure; drv ... See more keywords
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A Low Level of Darunavir Resistance–Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort

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recommendations! Published in 2020 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofaa567

Abstract: Abstract Background Ritonavir-boosted darunavir (DRV/r) is a protease inhibitor (PI) indicated for the treatment of naïve and pretreated HIV-infected patients since 2007. Our study aims to describe DRV/r-treated patients experiencing virological failure (VF) documented with… read more here.

Keywords: anrs co3; virological failure; drv; cohort ... See more keywords
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Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02251-21

Abstract: Fostemsavir is a prodrug of temsavir, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4+ T cells with demonstrated efficacy in phase 2 and 3.… read more here.

Keywords: attachment; fostemsavir; drv; cobicistat ... See more keywords
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RP-HPLC (STABILITY-INDICATING) BASED ASSAY METHOD FOR THE SIMULTANEOUS ESTIMATION OF DORAVIRINE, TENOFOVIR DISOPROXIL FUMARATE AND LAMIVUDINE

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recommendations! Published in 2021 at "International Journal of Applied Pharmaceutics"

DOI: 10.22159/ijap.2021v13i1.39608

Abstract: Objective: In this study, a RP-HPLC (stability-indicating) based assay method for the estimation of doravirine (DRV), tenofovir disoproxil fumarate (TFF) and lamivudine (LMV) simultaneously in the tablets was described. Methods: The simultaneous analysis of DRV,… read more here.

Keywords: hplc stability; assay method; tff; drv ... See more keywords
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The structural, dynamic, and thermodynamic basis of darunavir resistance of a heavily mutated HIV-1 protease using molecular dynamics simulation

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.927373

Abstract: The human immunodeficiency virus type 1 protease (HIV-1 PR) is an important enzyme in the life cycle of the HIV virus. It cleaves inactive pre-proteins of the virus and changes them into active proteins. Darunavir… read more here.

Keywords: drv; protease; molecular dynamics; resistance ... See more keywords
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Biodegradable polymeric nanocarriers for oral delivery of antiretroviral drug: Pharmacokinetic and in vitro permeability studies

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recommendations! Published in 2021 at "journal of applied pharmaceutical science"

DOI: 10.7324/japs.2021.110405

Abstract: The current work aimed to formulate Darunavir (DRV) loaded poly (ɛ-caprolactone) nanoparticles (NPs) to address the issue of low bioavailability. NPs were formulated by employing D-α Tocopherol Polyethylene Glycol Succinate 1,000 (TPGS) as stabilizer using… read more here.

Keywords: nanocarriers oral; drv; drug; delivery ... See more keywords