Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers
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DOI: 10.1093/jac/dky384
Abstract: Background Dolutegravir combined with darunavir/cobicistat is a promising NRTI-sparing and/or salvage strategy for the treatment of HIV-1 infection. Methods This Phase I, open-label, 57 day, crossover, pharmacokinetic (PK) study, enrolled healthy volunteers aged 18-65 years, who were… read more here.
Keywords: darunavir cobicistat; healthy volunteers; cobicistat; drv cobi ... See more keywords
Confirmation of the Drug–drug Interaction Potential between Cobicistat-boosted Antiretroviral Regimens and Hormonal Contraceptives
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DOI: 10.3851/imp3343
Abstract: Background Cobicistat (COBI), a CYP3A inhibitor, is a pharmacokinetic enhancer that increases exposures of the HIV protease inhibitors (PIs) atazanavir (ATV) and darunavir (DRV). The potential drug interaction between COBI-boosted PIs and hormonal contraceptives, which… read more here.
Keywords: cobi; drug interaction; drospirenone; atv cobi ... See more keywords