Fibroblast growth factor-21 alleviates phenotypic characteristics of dry age-related macular degeneration in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.109014
Abstract: Age-related macular degeneration (AMD) is the main cause of blindness in elderly individuals. As a metabolic regulator, fibroblast growth factor 21 (FGF-21) has been proven indicated to have an effect on wet AMD, but whether… read more here.
Keywords: age; degeneration; mice; age related ... See more keywords
Neutrophil-Lymphocyte Ratios in Dry Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2022.2092752
Abstract: Inflammation plays a role in the etiopathogenesis of age-related macular degeneration (AMD). A retrospective case-control study was conducted to assess the significance of the neutrophil-lymphocyte ratio (NLR) as a systemic inflammatory indicator in dry AMD.… read more here.
Keywords: related macular; age related; macular degeneration; age ... See more keywords
INCREASED INCIDENCE OF CUTANEOUS KERATINOCYTIC AND MELANOCYTIC MALIGNANCIES IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION.
Sign Up to like & getrecommendations! Published in 2019 at "Retina"
DOI: 10.1097/iae.0000000000002506
Abstract: PURPOSE The relationship between age-related macular degeneration (AMD) and malignancy, especially cutaneous malignancies, is not well studied. We investigated a possible association between AMD and cutaneous malignancies. METHODS A retrospective, consecutive review of all patients… read more here.
Keywords: wet amd; amd; dry amd; age ... See more keywords
Systemic immunosuppression and risk of age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203492
Abstract: A local immune response has been implicated in the pathogenesis of age-related macular degeneration (AMD), but it is unclear if systemic immunosuppressive/immunomodulatory therapy (IMT) protects against the onset and/or progression of AMD. We performed a… read more here.
Keywords: age related; dry amd; wet amd; wet ... See more keywords
Hot Topics in Dry AMD.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612822666161221154424
Abstract: BACKGROUND The global prevalence of AMD is projected to be 196 million by the year 2020. Despite substantial progress in the development of new therapies for wet AMD using inhibition of vascular endothelial growth factor… read more here.
Keywords: dry amd; topics dry; amd; hot topics ... See more keywords
Alterations of color vision and pupillary light responses in age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.933453
Abstract: Introduction Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries and one of the leading causes of blindness. In this work, we evaluated color vision and the pupil… read more here.
Keywords: patients early; early dry; color vision; dry amd ... See more keywords
The Association Between Diabetic Retinopathy and the Prevalence of Age-Related Macular Degeneration—The Kailuan Eye Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.922289
Abstract: This study aimed to investigate the prevalence of age-related macular degeneration (AMD) in patients with diabetes mellitus (DM) and diabetic retinopathy (DR) and analyze whether DR is a risk factor for AMD. This population-based epidemiological… read more here.
Keywords: prevalence; analysis; risk; amd ... See more keywords
Targeting the Complement Cascade for Treatment of Dry Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081884
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the elderly population. AMD is characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium… read more here.
Keywords: related macular; age related; macular degeneration; cascade ... See more keywords
RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043847
Abstract: Age-related macular degeneration (AMD) is the most common cause of blindness in the aged population. However, to date there is no effective treatment for the dry form of the disease, representing 85–90% of cases. AMD… read more here.
Keywords: rpe; gene therapy; therapy; gene ... See more keywords
The inhibition of NOTCH2 reduces UVB-induced damage in retinal pigment epithelium cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6625
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. The pathogenesis of dry AMD remains indistinct and the mechanism of retinal pigment epithelium (RPE) cells death in dry AMD is… read more here.
Keywords: dry amd; damage; rpe cells; inhibition notch2 ... See more keywords