PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
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DOI: 10.7554/elife.57117
Abstract: Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic approaches… read more here.
Keywords: hydroxymethylcytosine; enrichment; prdm9 binding; dsb activity ... See more keywords