Processing-Challenges Generated by Clusters of DNA Double-Strand Breaks Underpin Increased Effectiveness of High-LET Radiation and Chromothripsis.
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DOI: 10.1007/978-981-13-0593-1_10
Abstract: Whereas most endogenous and exogenous DNA damaging agents typically generate lesions that are relatively isolated and can be repaired easily, ionizing radiation (IR) also induces clustered lesions causing DNA double strand breaks (DSBs). Moreover, forms… read more here.
Keywords: dsb clusters; processing; chromothripsis; high let ... See more keywords