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   Articles with "dsba" as a keyword



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Soluble expression of IGF1 fused to DsbA in SHuffle™ T7 strain: optimization of expression and purification by Box-Behnken design

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recommendations! Published in 2019 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-019-09719-w

Abstract: Production of insulin-like growth factor 1 (IGF1) in Escherichia coli mostly results in the formation of inclusion bodies. In the present study, IGF1 was fused to disulfide bond oxidoreductase A (DsbA) and expressed in SHuffle™… read more here.

Keywords: dsba; igf1; expression; optimization ... See more keywords

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.04.044

Abstract: Background The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, and it plays a vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed… read more here.

Keywords: dsba; maintaining mam; microscopy; high glucose ... See more keywords
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Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.

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recommendations! Published in 2019 at "Kidney international"

DOI: 10.1016/j.kint.2018.10.038

Abstract: Ectopic fat deposition (EFD) in the kidney has been shown to play a causal role in diabetic nephropathy; however, the mechanism underlying EFD remains elusive. By transcriptome analysis, we found decreased expression levels of disulfide-bond… read more here.

Keywords: dsba; deposition; ectopic fat; diabetic nephropathy ... See more keywords
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DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity.

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recommendations! Published in 2023 at "Clinical science"

DOI: 10.1042/cs20220787

Abstract: Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprotection, but whether… read more here.

Keywords: dsba; mice; mam integrity; helz2 ... See more keywords
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A Buried Water Network Modulates the Activity of the Escherichia coli Disulphide Catalyst DsbA

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12020380

Abstract: The formation of disulphide bonds is an essential step in the folding of many proteins that enter the secretory pathway; therefore, it is not surprising that eukaryotic and prokaryotic organisms have dedicated enzymatic systems to… read more here.

Keywords: escherichia coli; dsba; activity; water network ... See more keywords

The Periplasmic Oxidoreductase DsbA Is Required for Virulence of the Phytopathogen Dickeya solani

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23020697

Abstract: In bacteria, the DsbA oxidoreductase is a crucial factor responsible for the introduction of disulfide bonds to extracytoplasmic proteins, which include important virulence factors. A lack of proper disulfide bonds frequently leads to instability and/or… read more here.

Keywords: periplasmic oxidoreductase; dsba; virulence; dsba required ... See more keywords