The novel axis of YAP1, transcription enhancer factor 3 and Down Syndrome Candidate Region 1 isoform 1L is a common signaling pathway downstream of several angiogenic factors.
Sign Up to like & getrecommendations! Published in 2019 at "Microvascular research"
DOI: 10.1016/j.mvr.2019.103955
Abstract: Angiogenesis is a hallmark of many diseases. Previously, we found that Down Syndrome Candidate Region 1 Isoform 1L (DSCR1-1L) was expressed in human tumor vessels, but was not detectable in normal tissues, and played important… read more here.
Keywords: yap1; growth; syndrome candidate; dscr1 ... See more keywords
Arsenic trioxide restrains lung cancer growth and metastasis by blocking the calcineurin-NFAT pathway by upregulating DSCR1.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220629154619
Abstract: BACKGROUND Anti-angiogenesis therapy mostly aimed at targeting vascular endothelial growth factor (VEGF) and its receptors has been widely applied to lung cancer. However, the improvement in the patient overall survival remains dissatisfying. Previously, we demonstrated… read more here.
Keywords: metastasis; lung cancer; growth; dscr1 ... See more keywords