Ultrasensitive colorimetric detection of NF-κB protein at picomolar levels using target-induced passivation of nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0783-y
Abstract: AbstractWe developed a highly sensitive and selective sensor based on the nanoprobe conjugates of catalytic nanoparticles and double-stranded DNA (dsDNA) for the colorimetric detection of NF-κB protein. The sensing mechanism takes advantage of the catalytic… read more here.
Keywords: colorimetric detection; detection; passivation; sensor ... See more keywords
In systemic lupus erythematosus anti-dsDNA antibodies can promote thrombosis through direct platelet activation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102355
Abstract: Systemic lupus erythematosus (SLE) is associated with a high risk of venous and arterial thrombosis, not necessarily associated with prothrombotic antiphospholipid antibodies (Abs). Alternatively, thrombosis may be due to an increased titer of anti-dsDNA Abs… read more here.
Keywords: thrombosis; dsdna abs; activation; anti dsdna ... See more keywords
A DNA electrochemical biosensor based on homogeneous hybridization for the determination of Cryptococcus neoformans
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2018.09.001
Abstract: Abstract The sensitive analysis of DNA is of extreme importance in the field of clinical diagnosis, targeted therapeutics, gene therapy, and a variety of biomedical studies. Even though significant achievements have been made in the… read more here.
Keywords: cryptococcus neoformans; dna; based homogeneous; homogeneous hybridization ... See more keywords
Electrochemical aptasensor for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards DpnII and Exo III digestion.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.01.010
Abstract: A simple and sensitive electrochemical method was developed for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards endonuclease DpnII activity. Without ampicillin, DNA aptamer firstly hybridizes with the capture probe to form… read more here.
Keywords: detection; exo iii; electrode surface; aptamer ... See more keywords
Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c24220
Abstract: DNA logic gates, nanocomputing circuits, have already implemented basic computations and shown great signal potential for nano logic material application. However, the reaction temperature and computing speed still limit its development. Performing complicated computations requires… read more here.
Keywords: realization triple; dna; nanocomputing circuits; design realization ... See more keywords
Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair
Sign Up to like & getrecommendations! Published in 2020 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c00312
Abstract: AlkB and its human homologue AlkBH2 are Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with mutagenic agents. We used molecular dynamics (MD) and combined quantum mechanics/molecular… read more here.
Keywords: dependent oxygenases; alkbh2; structural dynamics; repair ... See more keywords
Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b01377
Abstract: The toxicity of cadmium causes varying degrees of risk to organisms. The underlying mechanism has been conventionally attributed to Cd2+-ion-induced oxidative stress. Here, we propose that the Cd2+ ion directly and stably binds with the… read more here.
Keywords: major groove; ion; cadmium; thymine ... See more keywords
Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2820-9
Abstract: The strand-exchange reaction is central to homologous recombination. It is catalysed by the RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) and ATP. This filament binds to a donor double-stranded… read more here.
Keywords: dsdna; microscopy; dna; exchange ... See more keywords
Multiscale modelling reveals higher charge transport efficiencies of DNA relative to RNA independent of mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr02382e
Abstract: In this study, we compare the charge transport properties of multiple double-stranded (ds)RNA sequences with corresponding dsDNA sequences. Recent studies have presented a contradictory picture of relative charge transport efficiencies in A-form DNA : RNA hybrids and… read more here.
Keywords: transport efficiencies; charge transport; multiscale modelling; rna ... See more keywords
Cytosine methylation regulates DNA bendability depending on the curvature
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc07115g
Abstract: Cytosine methylation plays an essential role in many biological processes, such as nucleosome inactivation and regulation of gene expression. The modulation of DNA mechanics may be one of the regulatory mechanisms influenced by cytosine methylation.… read more here.
Keywords: methylation; cytosine methylation; depending curvature; mechanics ... See more keywords
Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa084
Abstract: Abstract Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress and pathogen invasion. The canonical activation mechanism of cGAS entails dsDNA-binding and dimerization. Here, we report an… read more here.
Keywords: cgas; mn2 dsdna; coupling mn2; activation ... See more keywords