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   Articles with "dsdna" as a keyword



Ultrasensitive colorimetric detection of NF-κB protein at picomolar levels using target-induced passivation of nanoparticles

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recommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-017-0783-y

Abstract: AbstractWe developed a highly sensitive and selective sensor based on the nanoprobe conjugates of catalytic nanoparticles and double-stranded DNA (dsDNA) for the colorimetric detection of NF-κB protein. The sensing mechanism takes advantage of the catalytic… read more here.

Keywords: colorimetric detection; detection; passivation; sensor ... See more keywords

In systemic lupus erythematosus anti-dsDNA antibodies can promote thrombosis through direct platelet activation.

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recommendations! Published in 2019 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2019.102355

Abstract: Systemic lupus erythematosus (SLE) is associated with a high risk of venous and arterial thrombosis, not necessarily associated with prothrombotic antiphospholipid antibodies (Abs). Alternatively, thrombosis may be due to an increased titer of anti-dsDNA Abs… read more here.

Keywords: thrombosis; dsdna abs; activation; anti dsdna ... See more keywords

A DNA electrochemical biosensor based on homogeneous hybridization for the determination of Cryptococcus neoformans

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recommendations! Published in 2018 at "Journal of Electroanalytical Chemistry"

DOI: 10.1016/j.jelechem.2018.09.001

Abstract: Abstract The sensitive analysis of DNA is of extreme importance in the field of clinical diagnosis, targeted therapeutics, gene therapy, and a variety of biomedical studies. Even though significant achievements have been made in the… read more here.

Keywords: cryptococcus neoformans; dna; based homogeneous; homogeneous hybridization ... See more keywords

Electrochemical aptasensor for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards DpnII and Exo III digestion.

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recommendations! Published in 2019 at "Talanta"

DOI: 10.1016/j.talanta.2019.01.010

Abstract: A simple and sensitive electrochemical method was developed for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards endonuclease DpnII activity. Without ampicillin, DNA aptamer firstly hybridizes with the capture probe to form… read more here.

Keywords: detection; exo iii; electrode surface; aptamer ... See more keywords

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips.

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recommendations! Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.1c24220

Abstract: DNA logic gates, nanocomputing circuits, have already implemented basic computations and shown great signal potential for nano logic material application. However, the reaction temperature and computing speed still limit its development. Performing complicated computations requires… read more here.

Keywords: realization triple; dna; nanocomputing circuits; design realization ... See more keywords

Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair

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recommendations! Published in 2020 at "ACS Central Science"

DOI: 10.1021/acscentsci.0c00312

Abstract: AlkB and its human homologue AlkBH2 are Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with mutagenic agents. We used molecular dynamics (MD) and combined quantum mechanics/molecular… read more here.

Keywords: dependent oxygenases; alkbh2; structural dynamics; repair ... See more keywords

Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine

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recommendations! Published in 2017 at "ACS Omega"

DOI: 10.1021/acsomega.7b01377

Abstract: The toxicity of cadmium causes varying degrees of risk to organisms. The underlying mechanism has been conventionally attributed to Cd2+-ion-induced oxidative stress. Here, we propose that the Cd2+ ion directly and stably binds with the… read more here.

Keywords: major groove; ion; cadmium; thymine ... See more keywords
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Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures

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recommendations! Published in 2020 at "Nature"

DOI: 10.1038/s41586-020-2820-9

Abstract: The strand-exchange reaction is central to homologous recombination. It is catalysed by the RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) and ATP. This filament binds to a donor double-stranded… read more here.

Keywords: dsdna; microscopy; dna; exchange ... See more keywords
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Multiscale modelling reveals higher charge transport efficiencies of DNA relative to RNA independent of mechanism.

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recommendations! Published in 2020 at "Nanoscale"

DOI: 10.1039/d0nr02382e

Abstract: In this study, we compare the charge transport properties of multiple double-stranded (ds)RNA sequences with corresponding dsDNA sequences. Recent studies have presented a contradictory picture of relative charge transport efficiencies in A-form DNA : RNA hybrids and… read more here.

Keywords: transport efficiencies; charge transport; multiscale modelling; rna ... See more keywords

Cytosine methylation regulates DNA bendability depending on the curvature

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recommendations! Published in 2022 at "Chemical Science"

DOI: 10.1039/d1sc07115g

Abstract: Cytosine methylation plays an essential role in many biological processes, such as nucleosome inactivation and regulation of gene expression. The modulation of DNA mechanics may be one of the regulatory mechanisms influenced by cytosine methylation.… read more here.

Keywords: methylation; cytosine methylation; depending curvature; mechanics ... See more keywords

B-105 Farr Radioimmunoprecipitation Method Enhances Serial Monitoring of Quantitative Anti-dsDNA (double-stranded) Antibody Measurements in Lupus

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recommendations! Published in 2024 at "Clinical Chemistry"

DOI: 10.1093/clinchem/hvae106.467

Abstract: Anti-double stranded DNA (anti-dsDNA) antibodies are an important criterion in the diagnosis, classification, and management of systemic lupus erythematous (SLE). High avidity anti-dsDNA IgG may be more clinically relevant and specific for SLE. As such,… read more here.

Keywords: farr ripa; method; serial monitoring; dsdna ... See more keywords