A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03125-y
Abstract: PurposePreclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant… read more here.
Keywords: phase study; gbm; tmz; dsf ... See more keywords
Numerical study of thermal characteristics of double skin facade system with middle shade
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Energy"
DOI: 10.1007/s11708-017-0480-8
Abstract: Architectural shade is an effective method for improving building energy efficiency. A new shade combined with the double skin façade (DSF) system, called middle shade (MS), was introduced and developed for buildings. In this paper,… read more here.
Keywords: dsf; temperature; indoor temperature; middle shade ... See more keywords
Modelling double skin façades (DSFs) in whole-building energy simulation tools: Validation and inter-software comparison of a mechanically ventilated single-story DSF
Sign Up to like & getrecommendations! Published in 2021 at "Building and Environment"
DOI: 10.1016/j.buildenv.2021.107906
Abstract: Abstract Double skin facades (DSFs) have been proposed as responsive building systems to improve the building envelope’s performance. Reliable simulation of DSF performance is a prerequisite to support the design and implementation of these systems… read more here.
Keywords: performance; building energy; dsf; building ... See more keywords
The clinical and economic impact of the use of diabetes-specific enteral formula on ICU patients with type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2016.09.027
Abstract: BACKGROUND & AIMS Patients admitted to intensive care units (ICUs) often need enteral nutrition (EN) support. For patients with type 2 diabetes (T2D), standard EN formulas may not provide ideal nutrients. The purpose was to… read more here.
Keywords: diabetes specific; patients type; dsf; formula ... See more keywords
Hydration of Portland cement paste mixed with densified silica fume: From the point of view of fineness
Sign Up to like & getrecommendations! Published in 2021 at "Construction and Building Materials"
DOI: 10.1016/j.conbuildmat.2020.121906
Abstract: Abstract To be easily transported and stored, silica fume is commonly densified before using in concrete. The size of densified silica fume (DSF) agglomeration is up to several millimeters. In general, the agglomeration is hard… read more here.
Keywords: hydration portland; dsf; silica fume; cement ... See more keywords
Development and characterisation of disulfiram‐loaded PLGA nanoparticles for the treatment of non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.11.032
Abstract: Graphical abstract Figure. No caption available. Abstract Non‐Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer in both men and women. A recent phase IIb study demonstrated that disulfiram (DSF) in… read more here.
Keywords: dsf; plga nanoparticles; lung cancer; non small ... See more keywords
Disulfiram/copper shows potent cytotoxic effects on myelodysplastic syndromes via inducing Bip-mediated apoptosis and suppressing autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174107
Abstract: Patients with myelodysplastic syndromes (MDS) who resist or fail to respond to hypomethylating agents (HMAs) show very poor outcomes and have no effective treatment strategies. Therefore, new therapeutic approaches are urgently needed for MDS patients… read more here.
Keywords: myelodysplastic syndromes; cytotoxic effects; dsf; shows potent ... See more keywords
Disulfiram-loaded mixed nanoparticles with high drug-loading and plasma stability by reducing the core crystallinity for intravenous delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.05.057
Abstract: To develop an injectable formulation and improve the stability of disulfiram (DSF), DSF was encapsulated into mixed nanoparticles (DSF-NPs) through a high-pressure homogenization method. The Flory-Huggins interaction parameters (χFH) were calculated to predict the miscibility… read more here.
Keywords: drug loading; dsf; stability; dsf nps ... See more keywords
Comparative investigation on building energy performance of double skin façade (DSF) with interior or exterior slat blinds
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Building Engineering"
DOI: 10.1016/j.jobe.2018.08.012
Abstract: Abstract Advanced passive control technologies attract a great deal of attention by architects and engineers as a way of achieving both high indoor environmental quality and energy efficient buildings. This study investigates the thermal and… read more here.
Keywords: dsf; energy; control; model ... See more keywords
Delivery of repurposed disulfiram by aminated mesoporous silica nanoparticles for anticancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117065
Abstract: Abstract Herein, aminated mesoporous silica nanoparticles (AMPSNPs) were developed by using the co-condensation process and were further explored as a nanocarrier for disulfiram (DSF) delivery, which is classified as a “repurposed drug” for a variety… read more here.
Keywords: microscopy; silica nanoparticles; dsf; aminated mesoporous ... See more keywords
Copper (α)/cis-platinum-loaded nanogels as an adjuvant potentiate disulfiram's antitumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01795k
Abstract: Disulfiram (DSF) is nontoxic and exerts anticancer activity by forming highly toxic chelates via its metabolite diethyldithiocarbamate with transition metal ions. However, there are not enough such ions in the human body to maintain the… read more here.
Keywords: disulfiram; antitumor efficacy; copper; cis platinum ... See more keywords