Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function
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DOI: 10.1371/journal.pone.0182445
Abstract: Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8. In structural analogy to most… read more here.
Keywords: dsrbd; rna binding; double stranded; stranded rna ... See more keywords
Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2
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DOI: 10.2210/pdb5oc4/pdb
Abstract: Double stranded RNA-binding domain (dsRBD) is a ubiquitous domain specialized in the recognition of double-stranded RNAs (dsRNAs). Present in many proteins and enzymes involved in various functional roles of RNA metabolism, including RNA splicing, editing,… read more here.
Keywords: dihydrouridine; dsrbd; double stranded; stranded rna ... See more keywords