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   Articles with "dsrna binding" as a keyword



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Accelerated delivery of dsRNA in lepidopteran midgut cells by a Galanthus nivalis lectin (GNA)-dsRNA-binding domain fusion protein.

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recommendations! Published in 2021 at "Pesticide biochemistry and physiology"

DOI: 10.1016/j.pestbp.2021.104853

Abstract: Lepidopteran insects are highly refractory to oral RNA interference (RNAi). Degradation, impaired cellular uptake and intracellular transport of double-stranded RNA (dsRNA) are considered the major factors responsible for the reduced RNAi efficiency in these insects.… read more here.

Keywords: rnai; dsrna; dsrna binding; fusion protein ... See more keywords

fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA.

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recommendations! Published in 2019 at "Methods"

DOI: 10.1016/j.ymeth.2018.06.004

Abstract: CLIP-seq (crosslinking immunoprecipitation and sequencing) is widely used to map the binding sites of a protein of interest on the transcriptome, and generally employs UV to induce the covalent bonds between protein and RNA, which… read more here.

Keywords: seq; binding proteins; drosha; dsrna binding ... See more keywords

Conformational Plasticity in dsRNA-Binding Domains Drives Functional Divergence in RNA Recognition.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c02057

Abstract: The functional specificity of proteins is often attributed to their sequence and structural homology while frequently neglecting the underlying conformational dynamics occurring at different time scales that can profoundly impact biological consequences. Using 15N-CEST NMR… read more here.

Keywords: functional divergence; recognition; plasticity; dsrna binding ... See more keywords

Identification of whole-cell dsRNA-binding proteins by phase separation

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recommendations! Published in 2024 at "RNA Biology"

DOI: 10.1080/15476286.2024.2386498

Abstract: ABSTRACT Interactions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA. The identification of dsRNA-binding proteins (dsRBPs) is key; however, it… read more here.

Keywords: phase separation; dsrna; binding proteins; identification ... See more keywords

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx667

Abstract: Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3′ untranslated regions (3′UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and… read more here.

Keywords: editing dsrna; rna; rna editing; dsrna binding ... See more keywords