Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus.
Sign Up to like & getrecommendations! Published in 2019 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2019.03.008
Abstract: In Drosophila melanogaster, transformer-2 (tra2) plays an essential role in the sex-specific splicing of doublesex (dsx) and fruitless (fru), two key transcription factor genes that program sexual differentiation and regulate sexual behavior. In the present… read more here.
Keywords: two three; three tra2; ovarian development; tra2 ... See more keywords
Tissue-specific developmental regulation and isoform usage underlie the role of doublesex in sex differentiation and mimicry in Papilio swallowtails
Sign Up to like & getrecommendations! Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.200792
Abstract: Adaptive phenotypes often arise by rewiring existing developmental networks. Co-option of transcription factors in novel contexts has facilitated the evolution of ecologically important adaptations. doublesex (dsx) governs fundamental sex differentiation during embryonic stages and has… read more here.
Keywords: dsx; tissue specific; sex differentiation;
Identification and Expression Analysis of Dsx and Its Positive Transcriptional Regulation of IAG in Black Tiger Shrimp (Penaeus monodon)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012701
Abstract: Doublesex (Dsx) is a polymorphic transcription factor of the DMRTs family, which is involved in male sex trait development and controls sexual dimorphism at different developmental stages in arthropods. However, the transcriptional regulation of the… read more here.
Keywords: transcriptional regulation; dsx; penaeus monodon; expression ... See more keywords
Nucleoporin107 mediates female sexual differentiation via Dsx
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72632
Abstract: We recently identified a missense mutation in Nucleoporin107 (Nup107; D447N) underlying XX-ovarian-dysgenesis, a rare disorder characterized by underdeveloped and dysfunctional ovaries. Modeling of the human mutation in Drosophila or specific knockdown of Nup107 in the… read more here.
Keywords: mediates female; dsx; nucleoporin107 mediates; bmp signaling ... See more keywords