Absence of developmental and reproductive toxicity in animals exposed to dolutegravir.
Sign Up to like & getrecommendations! Published in 2019 at "Birth defects research"
DOI: 10.1002/bdr2.1635
Abstract: The success of new antiretroviral medicines for HIV resulted in a change to guidelines of standard therapy where continuation of antiretroviral therapy is recommended to maintain the low viral load during pregnancy, thereby preventing transmission… read more here.
Keywords: absence developmental; pregnancy; dtg; exposure ... See more keywords
Virologic Outcomes Among ART-Naïve Individuals Initiating Dolutegravir, Elvitegravir, Raltegravir or Darunavir: An Observational Study
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-019-00274-5
Abstract: Introduction Dolutegravir (DTG), Elvitegravir (EVG), Raltegravir (RAL) and Darunavir (DRV) are commonly prescribed core agents for antiretroviral therapy (ART), and a need exists to compare their clinical effectiveness, as defined by virologic failure risks in… read more here.
Keywords: ral drv; dtg; virologic failure; drv ... See more keywords
CYP1A1 and 1B1‐mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.012
Abstract: &NA; Dolutegravir (DTG), a potent integrase inhibitor, is part of a recommended initial regimen for the treatment of human immunodeficiency virus (HIV). Prior reports demonstrated that the clearance of DTG was higher in current smokers… read more here.
Keywords: cyp1a1 1b1; metabolic pathways; dtg; mediated metabolic ... See more keywords
Thermal characterization of crude oils in the presence of limestone matrix by TGA-DTG-FTIR
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Petroleum Science and Engineering"
DOI: 10.1016/j.petrol.2017.02.001
Abstract: Abstract In present work oxidation of two heavy oils in limestone matrix was studied using simultaneous thermogravimetry (TGA), derivative thermogravimetry (DTG) and FTIR-spectroscopy techniques in the temperature range from 25 to 900 °C. Before the measurements,… read more here.
Keywords: dtg; temperature oxidation; crude oils; oxidation ... See more keywords
Liposome-encapsulated glycyrrhizin alleviates hyperglycemia and glycation-induced iron-catalyzed oxidative reactions in streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2022.2036756
Abstract: Abstract Glycyrrhizin, a bioactive constituent of Glycyrrhiza glabra has been reported to ameliorate diabetes. Here, the effects of liposome-encapsulated glycyrrhizin on STZ-induced diabetes and associated oxidative stress were investigated. Wistar rats were grouped as control… read more here.
Keywords: encapsulated glycyrrhizin; iron; dtg; dtbd ... See more keywords
An up-to-date evaluation of dolutegravir/abacavir/lamivudine for the treatment of HIV
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2029409
Abstract: ABSTRACT Introduction There are more than 30 agents available for the treatment of HIV with guidelines shifting toward integrase strand transfer inhibitors (INSTIs) as part of first line therapy. The fixed dose combination of dolutegravir… read more here.
Keywords: treatment hiv; hiv; treatment; dolutegravir ... See more keywords
Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2149490
Abstract: ABSTRACT Introduction Current recommended antiretroviral regimens include a combination of two (dual; DT) or three (triple; TT) antiretroviral drugs. This study aims to determine whether the quality of evidence from clinical trials of dolutegravir (dolutegravir/lamivudine… read more here.
Keywords: clinical trials; methodology; ftc taf; bic ftc ... See more keywords
Real world use of dolutegravir two drug regimens
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003480
Abstract: Background: Since 2015, we prescribed dolutegravir (DTG)-based two drug regimens (DTG-2DR) for 620 people [total cohort 3133 (19.8%)]. Method: Clinic database search 1 January 15 to 31 October 21. Demographic, tolerability and HIV related data… read more here.
Keywords: two drug; dtg 3tc; dtg rpv; dtg ... See more keywords
Uptake and discontinuation of integrase inhibitors (INSTIs) in a large cohort setting.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002250
Abstract: BACKGROUND Despite increased INSTI use, limited large-scale, real-life data exists on INSTI uptake and discontinuation. SETTING International multicohort collaboration. METHODS RESPOND participants starting dolutegravir (DTG), elvitegravir (EVG) or raltegravir (RAL) after 1/1/2012 were included. Predictors… read more here.
Keywords: uptake discontinuation; dtg evg; toxicity; evg ral ... See more keywords
Effect of Dolutegravir and multi-month dispensing on viral suppression among children with HIV.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000003190
Abstract: BACKGROUND Few studies in sub-Saharan Africa have assessed the impact of multi-month dispensing (MMD) of antiretroviral therapy (ART) and dolutegravir (DTG) beyond clinical trials among children with HIV (CWHIV). We assessed the effect of the… read more here.
Keywords: month dispensing; effect; among children; dtg ... See more keywords
Forgiveness of INSTI-Containing Regimens at Drug Concentrations Simulating Variable Adherence In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02038-21
Abstract: The integrase strand transfer inhibitor (INSTI)-based regimens bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF), dolutegravir (DTG)+FTC/TAF, DTG/lamivudine (3TC), and DTG/rilpivirine (RPV) are all approved for treatment of HIV-infected patients, with various limitations. Here, time to in vitro viral breakthrough… read more here.
Keywords: drug; resistance; ftc taf; dtg ... See more keywords