Absence of developmental and reproductive toxicity in animals exposed to dolutegravir.
Sign Up to like & getrecommendations! Published in 2019 at "Birth defects research"
DOI: 10.1002/bdr2.1635
Abstract: The success of new antiretroviral medicines for HIV resulted in a change to guidelines of standard therapy where continuation of antiretroviral therapy is recommended to maintain the low viral load during pregnancy, thereby preventing transmission… read more here.
Keywords: absence developmental; pregnancy; dtg; exposure ... See more keywords
Quantification of deoxythioguanosine in human DNA with LC-MS/MS, a marker for thiopurine therapy optimisation
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05581-6
Abstract: In the treatment of diseases such as acute childhood leukaemia (ALL) and inflammatory bowel disease (IBD), the thiopurines azathioprine, 6-mercaptopurine, and 6-thioguanine are used. Thiopurines are antimetabolites and immunomodulators used to maintain remission in patients.… read more here.
Keywords: deoxythioguanosine; deoxythioguanosine human; quantification deoxythioguanosine; dtg ... See more keywords
Virologic Outcomes Among ART-Naïve Individuals Initiating Dolutegravir, Elvitegravir, Raltegravir or Darunavir: An Observational Study
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-019-00274-5
Abstract: Introduction Dolutegravir (DTG), Elvitegravir (EVG), Raltegravir (RAL) and Darunavir (DRV) are commonly prescribed core agents for antiretroviral therapy (ART), and a need exists to compare their clinical effectiveness, as defined by virologic failure risks in… read more here.
Keywords: ral drv; dtg; virologic failure; drv ... See more keywords
CYP1A1 and 1B1‐mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.012
Abstract: &NA; Dolutegravir (DTG), a potent integrase inhibitor, is part of a recommended initial regimen for the treatment of human immunodeficiency virus (HIV). Prior reports demonstrated that the clearance of DTG was higher in current smokers… read more here.
Keywords: cyp1a1 1b1; metabolic pathways; dtg; mediated metabolic ... See more keywords
Thermal characterization of crude oils in the presence of limestone matrix by TGA-DTG-FTIR
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Petroleum Science and Engineering"
DOI: 10.1016/j.petrol.2017.02.001
Abstract: Abstract In present work oxidation of two heavy oils in limestone matrix was studied using simultaneous thermogravimetry (TGA), derivative thermogravimetry (DTG) and FTIR-spectroscopy techniques in the temperature range from 25 to 900 °C. Before the measurements,… read more here.
Keywords: dtg; temperature oxidation; crude oils; oxidation ... See more keywords
Liposome-encapsulated glycyrrhizin alleviates hyperglycemia and glycation-induced iron-catalyzed oxidative reactions in streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2022.2036756
Abstract: Abstract Glycyrrhizin, a bioactive constituent of Glycyrrhiza glabra has been reported to ameliorate diabetes. Here, the effects of liposome-encapsulated glycyrrhizin on STZ-induced diabetes and associated oxidative stress were investigated. Wistar rats were grouped as control… read more here.
Keywords: encapsulated glycyrrhizin; iron; dtg; dtbd ... See more keywords
An up-to-date evaluation of dolutegravir/abacavir/lamivudine for the treatment of HIV
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2029409
Abstract: ABSTRACT Introduction There are more than 30 agents available for the treatment of HIV with guidelines shifting toward integrase strand transfer inhibitors (INSTIs) as part of first line therapy. The fixed dose combination of dolutegravir… read more here.
Keywords: treatment hiv; hiv; treatment; dolutegravir ... See more keywords
Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2023.2149490
Abstract: ABSTRACT Introduction Current recommended antiretroviral regimens include a combination of two (dual; DT) or three (triple; TT) antiretroviral drugs. This study aims to determine whether the quality of evidence from clinical trials of dolutegravir (dolutegravir/lamivudine… read more here.
Keywords: clinical trials; methodology; ftc taf; bic ftc ... See more keywords
Dolutegravir with enteral feeds in intensive care: nutrition vs viral suppression
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Pharmacy Practice"
DOI: 10.1093/ijpp/riae058.015
Abstract: People living with HIV requiring admission to intensive care often receive enteral nutrition via feeding tubes. Enteral feeds contain cations which may interfere with dolutegravir (DTG) absorption due to chelation1. For this reason, temporal spacing… read more here.
Keywords: nutrition; care; temporal spacing; intensive care ... See more keywords
Real world use of dolutegravir two drug regimens
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003480
Abstract: Background: Since 2015, we prescribed dolutegravir (DTG)-based two drug regimens (DTG-2DR) for 620 people [total cohort 3133 (19.8%)]. Method: Clinic database search 1 January 15 to 31 October 21. Demographic, tolerability and HIV related data… read more here.
Keywords: two drug; dtg 3tc; dtg rpv; dtg ... See more keywords
Switch to bictegravir/emtricitabine/tenofovir alafenamide from dolutegravir-based therapy
Sign Up to like & getrecommendations! Published in 2024 at "AIDS"
DOI: 10.1097/qad.0000000000003865
Abstract: Objective: To evaluate the efficacy and safety of 96 weeks of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) treatment in participants switching from dolutegravir (DTG)-based therapy. Design: Studies 1489 (NCT02607930) and 1490 (NCT02607956) were phase 3 randomized, double-blind, active-controlled, first-line… read more here.
Keywords: treatment; therapy; tenofovir alafenamide; dtg ... See more keywords