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   Articles with "dtp cells" as a keyword



Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK ‐fusion‐positive lung cancer

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13746

Abstract: Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK‐TKIs) via emergence of a subpopulation of drug‐tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations. DTP… read more here.

Keywords: cell; inhibitor; gpx4; bypass ... See more keywords

Abstract 425: Characterization of TKI-induced drug-tolerant persister cells from a patient-derived cell line

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-425

Abstract: Introduction: Targeted therapies provide clinical benefits in patients harboring oncogene-driven cancers, but relapses invariably occur. Studies on resistance mechanisms are essential to guide the development of next-generation inhibitors. An increasing number of studies focus on… read more here.

Keywords: cell; tolerant; dtp cells; drug ... See more keywords

Drug-tolerant persister cells in acute myeloid leukemia: pressing challenge and promising new strategies for treatment

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recommendations! Published in 2025 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2025.1586552

Abstract: Acute myeloid leukemia (AML) exhibits a pronounced ability to develop drug resistance and undergo disease relapse. Recent research has noticed that resistance to treatments could substantially be attributed to drug-tolerant persister (DTP) cells, which are… read more here.

Keywords: persister; acute myeloid; drug; myeloid leukemia ... See more keywords

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14102562

Abstract: Simple Summary Drug tolerant persister (DTP) cells are a unique, small sub-population of cancer cells that maintain viability under anti-cancer cytotoxic treatments. These cells enter into a reversible drug-tolerant state, which is believed to be… read more here.

Keywords: breast cancer; dtp cells; gdf15; biomarker ... See more keywords