Additive naftopidil treatment synergizes docetaxel-induced apoptosis in human prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2536-x
Abstract: AbstractPurposeDocetaxel (DTX) is a standard chemotherapeutic drug for castration-resistant prostate cancer (CRPC), although adverse events are common. To overcome this problem, researchers have evaluated the efficacy of DTX treatment in combination with other drugs. Naftopidil… read more here.
Keywords: combination; treatment; induced apoptosis; dtx ... See more keywords
Development of self-assembled nanocarriers to enhance antitumor efficacy of docetaxel trihydrate in MDA-MB-231 cell line.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.12.130
Abstract: Self-assembled nanocarriers (SANs) as a novel colloidal controlled delivery for docetaxel trihydrate (DTX) were engineered by high-pressure homogenization method to overcome the several clinical problems. Drug-excipient compatibility was studied using DSC and FTIR spectroscopy. The… read more here.
Keywords: assembled nanocarriers; docetaxel trihydrate; mda 231; self assembled ... See more keywords
Blood‐brain barrier‐penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2016.12.019
Abstract: Abstract Brain metastasis is a fatal disease with limited treatment options and very short survival. Although systemic chemotherapy has some effect on peripheral metastases of breast cancer, it is ineffective in treating brain metastasis due… read more here.
Keywords: treatment; dtx; brain; breast cancer ... See more keywords
Co‐delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.09.042
Abstract: ABSTRACT The lysosomal degradation pathway of autophagy has a crucial role in protecting cancer cells from multiple endogenous and exogenous stresses, particularly during the pathogenesis of cancer. Accordingly, agents that inhibit autophagy may have broad… read more here.
Keywords: treatment; delivery; breast cancer; dtx ... See more keywords
Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.11.013
Abstract: Abstract Overexpression of nuclear factor E2–related factor 2 (Nrf2) contributes to the chemotherapeutic resistance of non–small-cell lung cancer (NSCLC). Docetaxel (DTX) is widely used for chemotherapy of NSCLC. However, resistance to DTX often result in… read more here.
Keywords: acid based; lung cancer; dtx; hyaluronic acid ... See more keywords
Lipid core nanoparticles as vehicle for docetaxel reduces atherosclerotic lesion, inflammation, cell death and proliferation in an atherosclerosis rabbit model.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2019.02.003
Abstract: Chemotherapeutic agents used in cancer treatment associated to nanoparticles (LDE) that mimic the composition of low-density lipoprotein and buffer their toxicity can have strong anti-atherosclerosis action, as we showed in cholesterol-fed rabbits. Here, a novel… read more here.
Keywords: treatment; lde dtx; proliferation; dtx ... See more keywords
Co-delivery of Docetaxel and Disulfonate Tetraphenyl Chlorin in One Nanoparticle Produces Strong Synergism between Chemo- and Photodynamic Therapy in Drug-Sensitive and -Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00597
Abstract: Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity, and overcoming drug resistance, provided that optimized drug concentration ratios… read more here.
Keywords: tpcs2a; delivery; synergism; drug ... See more keywords
α3β1 Integrin-TargetingPolymersomal Docetaxel as an Advanced Nanotherapeutic for NonsmallCell Lung Cancer Treatment
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.0c01069.s001
Abstract: Docetaxel (DTX) widely used for treating nonsmall cell lung cancer (NSCLC) patients is associated with dose-limiting side effects, especially neurotoxicity and myelosuppression. Here, we have developed cyclic cNGQGEQc peptide-directed polymersomal docetaxel (cNGQ-PS-DTX) as a targeted… read more here.
Keywords: cngq dtx; advanced nanotherapeutic; dtx; lung cancer ... See more keywords
Rational Fabrication of Folate-Conjugated Zein/Soy Lecithin/Carboxymethyl Chitosan Core–Shell Nanoparticles for Delivery of Docetaxel
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01270
Abstract: The objective of this work is to design and fabricate a natural zein-based nanocomposite with core–shell structure for the delivery of anticancer drugs. As for the design, folate-conjugated zein (Fa-zein) was synthesized as the inner… read more here.
Keywords: dtx; core; zein; delivery ... See more keywords
Enhanced antitumor effect on intrapulmonary tumors of docetaxel lung-targeted liposomes in a rabbit model of VX2 orthotopic lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10530-8
Abstract: Allergic reactions and severe systemic toxicity are two major challenges for the clinical application of docetaxel (DTX) for treatment of non-small-cell lung cancer (NSCLC). We developed a novel lung-targeted DTX-loaded liposome (DTX-LP), an efficient drug… read more here.
Keywords: pathology; lung; dtx; lung cancer ... See more keywords
An effective strategy for development of docetaxel encapsulated gold nanoformulations for treatment of prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80529-1
Abstract: Nanoformulation based drug delivery is one of the most important research areas in the field of nanomedicine, which provides promising alternatives to the limitations of conventional chemotherapy. Nano drug delivery enables improved pharmacokinetic profile, bioavailability… read more here.
Keywords: prostate cancer; drug; dtx; cancer ... See more keywords