Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer.
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DOI: 10.1042/bst20220501
Abstract: Ubiquitination is a protein post-translational modification that affects protein localisation, stability and interactions. E3 ubiquitin ligases regulate the final step of the ubiquitination reaction by recognising target proteins and mediating the ubiquitin transfer from an… read more here.
Keywords: dtx3l; ubiquitin ligase; activities binding; domain ... See more keywords
DTX3L Enhances Type I Interferon Antiviral Response by Promoting the Ubiquitination and Phosphorylation of TBK1
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DOI: 10.1128/jvi.00687-23
Abstract: Our present study evaluated DTX3L as an antiviral molecule by promoting IFN production and establishing an IFN-β–ETS1–DTX3L–TBK1 positive-feedback loop as a novel immunomodulatory step to enhance interferon signaling and inhibit respiratory syncytial virus (RSV) infection.… read more here.
Keywords: tbk1; phosphorylation tbk1; dtx3l; response ... See more keywords
Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway
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DOI: 10.3390/ijms24010861
Abstract: Cervical carcinoma (CC) is the second most prevalent gynecologic cancer in females across the world. To obtain a better understanding of the mechanisms underlying the development of CC, high-resolution label-free mass spectrometry was performed on… read more here.
Keywords: pi3k akt; dtx3l; mtor signaling; akt mtor ... See more keywords