Potential Fungicide Candidates: A Dual Action Mode Study of Novel Pyrazole-4-carboxamides against Gibberella zeae.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06962
Abstract: Pyrazole carboxamides are a class of traditional succinate dehydrogenase inhibitors (SDHIs) that have developed into a variety of commercialized fungicides. In the present work, a series of novel 1,5-disubstituted-1H-pyrazole-4-carboxamide derivatives were designed and synthesized based… read more here.
Keywords: gibberella zeae; pyrazole carboxamides; microscopy; potential fungicide ... See more keywords
Dual Action of Hydrotropes at the Water/Oil Interface
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.7b05156
Abstract: Hydrotropes are substances containing small amphiphilic molecules, which increase solubility of nonpolar (hydrophobic) substances in water. Hydrotropes may form dynamic clusters (less or about 1 ns lifetime) with water molecules; such clusters can be viewed… read more here.
Keywords: action hydrotropes; dual action; water; interface ... See more keywords
Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.3c00408
Abstract: Here, we demonstrate the concerted inhibition of different influenza A virus (IAV) strains using a low-molecular-weight dual-action linear polymer. The 6'-sialyllactose and zanamivir conjugates of linear polyglycerol are optimized for simultaneous targeting of hemagglutinin and… read more here.
Keywords: dual action; heteromultivalent; virus; influenza virus ... See more keywords
Dual Action Nitric Oxide and Fluoride Ion-Releasing Hydrogels for Combating Dental Caries.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c02301
Abstract: Demineralization and breakdown of tooth enamel are characterized by a condition called dental caries or tooth decay, which is caused by two main factors: (1) highly acidic food intake without proper oral hygiene and (2)… read more here.
Keywords: oxide fluoride; nitric oxide; dual action; dental caries ... See more keywords
Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01771
Abstract: Controlled photoreduction of Pt(IV) prodrugs is a challenging task due to the possibility of targeted light-controlled activation of anticancer agents without affecting healthy tissues. Also, a conjugation of photosensitizers and clinically used platinum drugs into… read more here.
Keywords: reduction novel; photoinduced reduction; dual action; prodrug ... See more keywords
Fluorocarbon-Free Dual-Action Textile Finishes Based on Covalently Attached Thermoresponsive Block Copolymer Brush Coatings.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b11448
Abstract: We present fluorocarbon-free block copolymer brushes as potential systems for dual-action, i.e., soil-repellent and soil-releasing textile finishes. Polymer brushes were prepared by employing specifically engineered triblock copolymers consisting of a hydrophobic, a hydrophilic, and either… read more here.
Keywords: copolymer brush; block copolymer; block; dual action ... See more keywords
Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b22277
Abstract: The management of thrombosis and bacterial infection is critical to ensure the functionality of medical devices. While the administration of anticoagulants is the current antithrombotic clinical practice, a variety of complications such as uncontrolled hemorrhages… read more here.
Keywords: mimicking endothelium; dual action; surface; surface mimicking ... See more keywords
Small-Molecule Poly(ADP-ribose) Polymerase and PD-L1 Inhibitor Conjugates as Dual-Action Anticancer Agents
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01106
Abstract: Immune checkpoint blockades have revolutionized the treatment landscape for several cancer indications, yet they have not gained traction in a range of other tumors such as triple-negative breast cancer. Despite durable disease control by many… read more here.
Keywords: molecule; anticancer agents; dual action; small molecule ... See more keywords
Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30625-0
Abstract: The transient receptor potential canonical (TRPC) 1 channel is widely distributed in mammalian cells and is involved in many physiological processes. TRPC1 is primarily considered a regulatory subunit that forms heterotetrameric channels with either TRPC4… read more here.
Keywords: dual action; plc pathway; trpc1; heterotetrameric channels ... See more keywords
Dual-action organoplatinum polymeric nanoparticles overcoming drug resistance in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt01683j
Abstract: Drug resistance to the conventional platinum chemotherapy remains a major challenge for treating ovarian cancer. Herein, we present a novel approach to overcome the drug resistance by utilizing "dual-action" organometallic polymeric nanoparticles (OPNPs). The OPNPs… read more here.
Keywords: drug resistance; dual action; drug; ovarian cancer ... See more keywords
Dual action of a tyrosinase-mesoporous silica nanoparticle complex for synergistic tissue adhesion.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05678j
Abstract: Bridging biological tissues for immediate adhesion and long-term sustainability was accomplished using a combination of mesoporous silica nanoparticles (MSNs) and tyrosinase. Tyrosinase-loaded MSNs provided rapid physical adsorption, while tyrosinase within MSNs induced enzymatic chemical bond… read more here.
Keywords: adhesion; mesoporous silica; action tyrosinase; dual action ... See more keywords