What Makes a Good Protein–Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00003
Abstract: Protein–protein interactions (PPIs) are essential for biological processes including immune reactions and diseases. Inhibition of PPIs by drug-like compounds is a common basis for therapeutic approaches. In many cases the flat interface of PP complexes… read more here.
Keywords: binding; protein protein; binding mechanism; mechanism ... See more keywords
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00656
Abstract: Acetylcholinesterase (AChE) inhibitors (AChEIs) still remain the leading therapeutic options for the symptomatic treatment of cognitive deficits associated with mild-to-moderate Alzheimer's disease. The search for new AChEIs benefits from well-established knowledge of the molecular interactions… read more here.
Keywords: ache; binding site; inhibitor; dual binding ... See more keywords
Identification of dual binding mode of Orthodiffenes towards human topoisomerase-I and α-tubulin: exploring the potential role in anti-cancer activity via in silico study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2039296
Abstract: Abstract The drugs prescribed for targeting the tumour growth comprise of chemotherapy regimen involving combinations to cell-cycle phase specific target receptors. The combination therapy with Topoisomerase-I (Topo-I) & anti-tubulin agents are in the clinical trial… read more here.
Keywords: via silico; topoisomerase; tubulin; study ... See more keywords
Dual binding motifs underpin the hierarchical association of perilipins1–3 with lipid droplets
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-08-0534
Abstract: Lipid droplets (LDs) in all eukaryotic cells are coated with at least one of the perilipin (Plin) family of proteins. They all regulate key intracellular lipases but do so to significantly different extents. Where more… read more here.
Keywords: hierarchical association; binding motifs; underpin hierarchical; motifs underpin ... See more keywords
Tetrel-Bond Interactions Involving Metallylenes TH2 (T = Si, Ge, Sn, Pb): Dual Binding Behavior
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DOI: 10.3390/molecules28062577
Abstract: The dual binding behavior of the metallylenes TH2 (T = Si, Ge, Sn, Pb) with some selected Lewis acids (T’H3F, T’ = Si, Ge, Sn, Pb) and bases (N2, HCN, CO, and C6H6) has been… read more here.
Keywords: type complexes; metallylenes th2; type; binding behavior ... See more keywords