Neoadjuvant Dual Checkpoint Inhibitors vs Anti-PD1 Therapy in High-Risk Resectable Melanoma
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2023.7333
Abstract: Key Points Question What is the optimal neoadjuvant regimen for patients with operable node-positive, high-risk stage III and IV melanoma? Findings In this pooled analysis of 573 patients from 6 clinical trials, the risk for… read more here.
Keywords: melanoma; high risk; neoadjuvant dual; checkpoint ... See more keywords
The dual checkpoint blockade in unresectable hepatocellular carcinoma: opportunities emerging in clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2042253
Abstract: ABSTRACT Introduction To prevent damage from an immune response against autoantigens and toxins originating from the gut, the liver promotes an immune-tolerant milieu providing fertile ground for immune escape of cancer cells. Therefore, the use… read more here.
Keywords: blockade; dual icis; hepatocellular carcinoma; dual checkpoint ... See more keywords
Efficacy of dual checkpoint inhibitors in a patient with a mixed hepatocellular cholangiocarcinoma
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DOI: 10.1136/bcr-2023-255003
Abstract: A woman in her 60s was diagnosed with a metastatic, unresectable rare histological type of liver cancer; combined hepatocellular cholangiocarcinoma. She had palliative chemotherapy, initially with gemcitabine and cisplatin, and then with oxaliplatin, L-folinic acid… read more here.
Keywords: efficacy dual; hepatocellular cholangiocarcinoma; dual checkpoint; cholangiocarcinoma ... See more keywords
Abstract 4644: Real-world outcomes in dual checkpoint inhibitor therapy: A single community center perspective
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DOI: 10.1158/1538-7445.am2025-4644
Abstract: Immunotherapy using dual checkpoint inhibitors is used to induce an antitumor response towards cancer. The varied response in treatment outcomes for those who receive dual checkpoint may be influenced by many factors. We attempted to… read more here.
Keywords: cancer; dual immunotherapy; immunotherapy; dual checkpoint ... See more keywords
Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response—A Case Report
Sign Up to like & getrecommendations! Published in 2024 at "Medicina"
DOI: 10.3390/medicina60071129
Abstract: Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related… read more here.
Keywords: treatment; complete response; case; checkpoint ... See more keywords