Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities
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DOI: 10.1016/j.molstruc.2021.130565
Abstract: Abstract Herein, two novel series of diaryl-1,2,4-triazole hybrid to amide conjugates (5a-e) or urea conjugates (10a-f) have been synthesized followed by in vitro evaluation against cyclo-oxygenase-2/soluble epoxide hydrolase (COX-2/sEH) enzymes using ELISA enzyme assays. In… read more here.
Keywords: diaryl triazole; dual cox; inflammatory analgesic; anti inflammatory ... See more keywords