One-step fabrication of bicompartmental microparticles as a dual drug delivery system for Parkinson’s disease management
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science"
DOI: 10.1007/s10853-018-2819-x
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily affecting elderly patients. In order to efficiently manage the symptoms of the disease, controlled and continuous supply of PD drugs [levodopa (LD) and carbidopa (CD)] would… read more here.
Keywords: system; microscopy; disease; drug ... See more keywords
An electrospun fiber-covered stent with programmable dual drug release for endothelialization acceleration and lumen stenosis prevention.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.06.008
Abstract: Aneurysmal subarachnoid hemorrhage (SAH) causes high rates of mortality and morbidity. A covered stent is an effective endovascular treatment for complicated aneurysms intractable to endovascular coiling and surgical clipping. However, in-stent restenosis and delayed endothelialization… read more here.
Keywords: endothelialization; drug loaded; covered stent; drug ... See more keywords
Dual drug delivery and sequential release by amphiphilic Janus nanoparticles for liver cancer theranostics.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.07.060
Abstract: Co-delivery of two drugs with diverse physicochemical properties and specific administration order for cancer theranostics are vitally important for drug resistance conquering and side effects reducing. Consequently, we explored a unique amphiphilic PCL-AuNC/Fe(OH)3-PAA Janus nanoparticle… read more here.
Keywords: delivery; drug; cancer; dual drug ... See more keywords
Multi-layer nanofibrous tubes with dual drug-release profiles for vascular graft engineering
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.01.015
Abstract: Abstract Currently available synthetic grafts demonstrate moderate success at the macrovascular level, but there is still a problem with thrombus formation at the microvascular scale ( read more here.
Keywords: dual drug; layer nanofibrous; nanofibrous tubes; drug ... See more keywords
Effect on in-vitro release of individual and dual contraceptive drug loading from gelatin electrospun fibers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.03.026
Abstract: Abstract The transdermal route of drug administration provides many advantages for delivering a wide variety of drugs or other beneficial agents. The aim of this work was to investigate the suitability of electrospinning process to… read more here.
Keywords: dual drug; drug; drug loading; release ... See more keywords
Simultaneous delivery of paclitaxel and erlotinib from dual drug loaded PLGA nanoparticles: Formulation development, thorough optimization and in vitro release
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.02.091
Abstract: Abstract The current approach involves the development of dual drug loaded nanoparticles of Paclitaxel (Pac) and Erlotinib (Erl) with subsequent thorough optimization in order to achieve sustained and simultaneous delivery of Pac and Erl. The… read more here.
Keywords: paclitaxel erlotinib; formulation; optimization; dual drug ... See more keywords
Cisplatin-Conjugated Polyurethane Capsule for Dual Drug Delivery to a Cancer Cell.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c22146
Abstract: This paper describes the synthesis of a polymer-prodrug conjugate, its aqueous self-assembly, noncovalent encapsulation of a second drug, and stimuli-responsive intracellular dual drug delivery. Condensation polymerization between a functionalized diol and a commercially available diisocyanate… read more here.
Keywords: cell; prodrug; drug delivery; dual drug ... See more keywords
Fabrication and characterization of dual drug-loaded poly (lactic-co-glycolic acid) fiber-microsphere composite scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2018.1446139
Abstract: ABSTRACT The purpose of this work is to develop dual drug-loaded poly (lactic-co-glycolic acid) (PLGA) fiber-microsphere composite scaffolds with desired morphologies and dual drug loading properties, and to investigate the release kinetics of the dual… read more here.
Keywords: fiber microsphere; microsphere composite; drug; dual drug ... See more keywords
pH sensitive supramolecular vesicles from cyclodextrin graft copolymer and benzimidazole ended block copolymer as dual drug carriers
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2018.1493686
Abstract: Abstract Supramolecular assemblies from chitosan-graft-β-cyclodextrin (CS-g-CD) and benzimidazole ended poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL-BM) were formed based on the inclusion complexation between β-cyclodextrin and benzimidazole. The supra-amphiphiles self-assembled into complex vesicles with PCL/β-CD as the hydrophobic membrane,… read more here.
Keywords: graft; benzimidazole ended; drug; dual drug ... See more keywords
A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2016.1228716
Abstract: Abstract Exploration of efficient dual-drug nanohybrids, particularly those with high drug loading, specific targeting property, and long-termed stability, is of highly importance in cancer therapy. A pH-driven coprecipitation was performed in the aqueous phase to… read more here.
Keywords: drug nanoformulations; green approach; drug; dual drug ... See more keywords
Molecularly engineering a dual-drug nanoassembly for self-sensitized photodynamic therapy via thioredoxin impairment and glutathione depletion
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2141920
Abstract: Abstract Photodynamic therapy (PDT) has been extensively investigated as a spatiotemporally noninvasive and controllable modality for cancer treatment. However, the intracellular antioxidant systems mainly consisting of thioredoxin (Trx) and glutathione (GSH) significantly counteract and prevent… read more here.
Keywords: antioxidant systems; photodynamic therapy; dual drug; drug nanoassembly ... See more keywords