DUAL INHIBITION OF EZH2 AND HDAC IS SYNERGISTIC IN EZH2 DYSREGULATED LYMPHOMAS
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_120
Abstract: rubicin, epirubicin, vinblastine, etoposide, paclitaxel, and topotecan. RTI‐79's PK characteristics are similar to rifabutin and exhibited no overt toxicity in mice at high doses. RTI‐79 did not exacerbate the known cardiotoxicity associated with doxorubicin as… read more here.
Keywords: rti; ezh2 hdac; dual inhibition; ezh2 ... See more keywords
Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.014
Abstract: The monotherapy of mTOR inhibitors (mTORi) in cancer clinical practice has achieved limited success due to the concomitant activation of compensatory pathways, such as Akt signaling and cytoprotective autophagy. Thus, the combination of mTORi and… read more here.
Keywords: cancer; bladder cancer; inhibition akt; dual inhibition ... See more keywords
Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.08.028
Abstract: INTRODUCTION PI3K pathway signaling has received attention as a molecular target in clear cell ovarian carcinoma (CCOC). MDM2 is one of the AKT effectors in the PI3K pathway, which binds to and degrades p53. In… read more here.
Keywords: mdm2; dual inhibition; expression; cell ... See more keywords
Dual inhibition of IL-17A and IL-17F in psoriatic disease
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/20406223211037846
Abstract: Psoriasis and psoriatic arthritis are chronic immune-mediated disorders with involvement of interleukin (IL)-17 cytokines in their pathogenesis. IL-17A has been considered to be the most biologically active, but IL-17F is also over-expressed in skin and… read more here.
Keywords: 17a 17f; inhibition 17a; disease; dual inhibition ... See more keywords
Dual Inhibition of H3K9me2 and H3K27me3 Promotes Tumor Cell Senescence without Triggering the Secretion of SASP
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073911
Abstract: Chemotherapy remains the most common cancer treatment. Although chemotherapeutic drugs induce tumor cell senescence, they are often associated with post-therapy tumor recurrence by inducing the senescence-associated secretory phenotype (SASP). Therefore, it is important to identify… read more here.
Keywords: senescence; tumor cell; cell senescence; tumor ... See more keywords
Dual Inhibition of HIV-1 and Cathepsin L Proteases by Sarcandra glabra
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175552
Abstract: The COVID-19 pandemic continues to impose a huge threat on human health due to rapid viral mutations. Thus, it is imperative to develop more potent antivirals with both prophylactic and treatment functions. In this study,… read more here.
Keywords: sarcandra glabra; protease; hiv; cathepsin ... See more keywords
Dual inhibition of EGFR-VEGF: An effective approach to the treatment of advanced non-small cell lung cancer with EGFR mutation (Review)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5474
Abstract: On a global scale, the incidence and mortality rates of lung cancer are gradually increasing year by year. A number of bad habits and environmental factors are associated with lung cancer, including smoking, second-hand smoke… read more here.
Keywords: lung cancer; cancer; egfr; egfr vegf ... See more keywords